Organic matter

  • Mandelalide structure

    Mandelalide A

    8 May 2014

    New reactions need to belong in a synthesis, says BRSM, not be forced in for show

  • amide reduction pathways

    Reduced to clear

    1 April 2014

    Karl Collins contemplates reducing amides to alcohols instead of amines

  • Inspecting reactor contents by torchlight

    Ringing the changes

    27 February 2014

    A chemical manufacturing plant is a whole new world compared to the lab, as Chemjobber explains

  • Indoxamycins A, C and F

    Indoxamycins A, C and F

    29 January 2014

    BRSM gets to the core of a divergent synthesis of this natural product family

  • Catalyst structure

    Oxidation station

    8 January 2014

    Pushing the boundaries of C-H activation with Karl Collins

  • Ciguatoxin CTX1B

    Gone to completion

    26 November 2013

    After a 66-step journey, Paul Docherty ponders the future of total synthesis in his final column

  • Marcfortines B (left) and C (right)

    Marcfortines B & C

    5 November 2013

    Paul Docherty ponders a tasty cheeseboard as a source of synthetic inspiration

  • 1013CW-TOT-SYN-Main_300

    Scholarisine A

    26 September 2013

    Paul Docherty marvels at a parade of intricate radical reactions

  • Steviol


    2 September 2013

    Sculpting a molecule from a larger whole is an unusual but effective strategy, says Paul Docherty

  • Opinion

    Melotenine A

    30 July 2013

    Paul Docherty extols the virtues of chiral heteroatoms