Derek Lowe

  • Dusty reagent bottles

    Death of a reagent

    22 August 2014

    Fashion and progress combine to mean some reactions and reagents persist, while others fall by the wayside, says Derek Lowe

  • Molecular structure in crystal ball

    The crystal ball that can tell lies

    29 July 2014

    X-ray structures are not necessarily definitive, says Derek Lowe, especially when it comes to biomolecules

  • CW0714_Pipeline_630m

    Too big to innovate?

    25 June 2014

    How strong is the correlation between company size and research productivity, asks Derek Lowe

  • 0614CW_PIPELINE_300m

    Messy megamergers

    29 May 2014

    Big company buyouts are more about immediate gains and rarely consider the impact on research, says Derek Lowe


    Engineering serendipity

    25 April 2014

    It takes more than random stumbling to find new reactions, says Derek Lowe

  • Man in respirator with smoking flask

    Known unknowns

    27 March 2014

    New molecules with unpredictable biological activity deserve sensible amounts of respect, says Derek Lowe

  • Mystery box concept image

    Tools of the trade

    24 February 2014

    Derek Lowe wonders what the most life-changing instrument for organic chemists is, and what might be missing from the toolbox

  • devilish manager at computer

    Beelzebub Pharma Ltd

    31 January 2014

    Derek Lowe thinks the Devil’s R&D management schemes might be scarily familiar

  • Hammer and nails

    Is there a drug for that?

    7 January 2014

    Derek Lowe ponders whether anything is truly ‘undruggable’ if we look in the right places

  • cartoon of workers pushing a boulder up a hill with a manager on the boulder

    Rolling boulders uphill

    27 November 2013

    Is Derek Lowe troubled by his failure to develop a compound that has made it to the pharmacy shelf?