All Clinical Trials articles
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BusinessAlzheimer’s antibody engenders anticipation
Tantalising press-released data on Biogen and Eisai’s lecanemab prompt questions without firm answers
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Opinion
May cause side effects
The dose makes the poison, but understanding unwanted drug interactions is complicated
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Opinion
Alzheimer’s, amyloid and abandoned antibodies
Biogen’s aducanumab is stumbling into obscurity. Where does that leave the amyloid hypothesis?
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News
New questions raised over Sputnik Covid vaccine results point to fraudulent practices
Analysis comparing Sputnik results with five other Covid vaccines finds phase 3 trial outcome is highly improbable
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Business
What is the future of Covid-19 pharmaceuticals?
Firms anticipate long-term markets for prevention and treatment
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Business
Trials start of mRNA vaccine for HIV
First steps towards protection from the many and variable viral strains
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Research
Engineered antibody that snags sperm could be an effective non-hormonal contraceptive
Approach could offer new method of contraception for women
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Business
Covid-19 antivirals surge forward
Promising results from Pfizer trial, while UK approves Merck & Co’s molnupiravir
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News
Hints that century-old TB vaccine offers an immune boost against Covid-19
Small study is part of global effort examining whether the BCG jab could help in the next pandemic
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News
Promotion of Covid-19 pseudoscience by Indian government criticised as pandemic rages
Questionable therapies under study or promoted include prayer, breathing exercises and herbal medicines
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Opinion
The side effects of being unique
Even the largest clinical trials won’t capture all possible bad reactions to a drug – we need pharmacovigilance
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Opinion
How the pandemic might change drug research
Derek Lowe muses on some positive lessons learned
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News
Green light for world’s first Sars-CoV-2 studies that will infect healthy volunteers
UK trials will assess how well Covid-19 treatments work and if vaccines protect against new virus variants
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Review
The Poison Trials: Wonder Drugs, Experiment, and the Battle for Authority in Renaissance Science
An extremely well-researched monograph containing stories that bear an eerie resemblance to today’s politicised clinical trials
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Business
Covid vaccination efforts bolstered by trial results from J&J and Novavax
A miserable January ended with positive news on the vaccine front but new variants added complications
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Business
Vaccine approvals offer hope as global Covid cases surge
A handful of vaccines are now approved and the first doses are being given to patients, with trials for many more candidates nearing completion
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Research
Explainer: How would UK science be affected by a no-deal Brexit?
Access to EU science schemes, freedom of movement and student places are all expected to be disrupted
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Business
Oxford–AstraZeneca vaccine joins others with promising interim data
Cheap and fridge-stable candidate at least 60% and up to 90% effective at preventing disease
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Business
Regulatory panel unconvinced by Alzheimer’s antibody evidence
US FDA advisors vote against approving Biogen’s aducanumab on the basis of incomplete data analysis
