Medicine and health – Page 4
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ResearchDiverse pharmaceutical building blocks prepared with evolved enzymes
Computation guides enzyme evolution to produce high-value drug compounds
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ResearchAmide library created at speed with machine learning and stopped-flow chemistry
Approach used 90% less starting material than continuous flow equivalent
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ResearchYeast engineered to ferment sugars into chemotherapy drug precursors
Semisynthesis offers new route to anticancer drug vinblastine
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ResearchArtificially evolved enzyme tackles tricky cross coupling
Directed evolution on the metalloenzyme cytochrome P450 creates a catalyst for making macrocyclic antibiotics
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ResearchCombining expertise to develop remote-controlled nanomaterials
Beatriz Pelaz explains how her research tackles bionanomaterials from multiple angles
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ResearchTeixobactin’s two pronged antibiotic attack mechanism revealed
Understanding of formation of deadly supramolecular structures could help build improved antimicrobials
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ResearchAntigen-carrying adjuvants activate both adaptive and innate immunity
Aluminosilicate nanoparticles promote ion perturbation, pyroptosis and enhanced immunity in a cancer model
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ResearchMolecular machine drills holes in antibiotic-resistant bacteria killing them
Bacteria aren’t able to develop resistance against nanomotor’s deadly action
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ResearchEncapsulated bacteria show promise as injectable living drugs factories to treat diseases
Engineered E. coli produce insulin and vaccines in vivo
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ResearchLight-activated cancer treatment uses tumour-targeting enzymes to cut side effects
Enzymatic activation of a photosensitive prodrug in cancerous cells shows promise in mice
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ResearchBreaking bacteria’s genetic silence to synthesise antibiotics that evade resistance
Prospecting in bacterial genomes offers hope in search for new antimicrobial drugs
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ResearchGene therapy showcases technique to extend life in mice
Lab mice lived significantly longer after receiving one of two genes, delivered using a mouse herpes virus
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ResearchGut microbiome analysis spots sleep-deprived mice
Fluorescence-based sensing array that identifies bacteria in stool samples could be developed into a tool for diagnosing various conditions
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ResearchThese 15 molecules trigger Covid smell disorder
Researchers identify compounds that trigger parosmia, the condition that makes coffee smell like burning rubbish
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ResearchCancer progression and harmful bacteria tracked with next-generation sequencing
Proof-of-principle study keeps an eye on leukaemia mutations and bacterial strains in patients
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ResearchYeast engineered to convert methanol into heparin
Production levels are currently low, but researchers hope the method could one day mean pharma doesn’t have to rely on animals for this essential medicine
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ResearchAI tool finds green ways to turn chemical waste into drugs
Circular approach for industry by-products considers environmental, economic and geographic aspects to rank predicted routes for real-world applications
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ResearchEdible, fluorescent silk tags could help stem tide of counterfeit medicines
Marker could be a simple answer to ensuring provenance of drugs
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ResearchPepto-Bismol compound’s structure unveiled after 120 years
Electron microscopy triumphed over x-ray crystallography as century-old structural puzzle around bismuth subsalicylate is finally solved
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ResearchDiscovery of microplastics in people raises difficult questions about health implications
Scientists keep finding tiny polymer particles in lungs, blood and placentas – but what does that mean means for people’s health?