Graham L Patrick

Oxford University Press

2013 | 789pp | £34.99

An introduction to medicinal chemistry is exactly that and more. It is an essential text aimed at undergraduates and postgraduates studying aspects of medicinal chemistry. Moreover, it is an indispensable handbook for established researchers looking to enter the multidisciplinary world of medicinal chemistry.

The book is split into five parts, covering key concepts such as biochemistry, pharmacodynamics and pharmacokinetics, drug discovery and development, synthesis and drug design, and ends with some selected topics used to highlight drug development programmes in important clinical areas. These topics contextualise the science described earlier in an approachable and thoroughly interesting way, journeying through the highs and lows of drug discovery. 

The structures, figures and schemes are clear and easy to follow and colour is used well, highlighting key points without being distracting. Chapters are helpfully signposted throughout, informing the reader how topics are related, which is especially important in such a multidisciplinary subject. Topics are also presented clearly and with a logical progression culminating in the Key points, Questions and Further reading sections at the end of each chapter, which include selected key references that are an excellent resource.

An assortment of case studies is provided and the author works through each one in great detail, giving an overall perspective on the science. Finally, very useful and informative appendices and a glossary are provided together with a comprehensive index that is good enough to rival any search engine!

There are many books that describe medicinal chemistry and its uses, but An introduction to medicinal chemistry stands out as it presents medicinal chemistry and its related topics in a clear, informative and interesting way that really demonstrates the application and impact of this fundamental subject in society.

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