Highlights

AI drug development

As AI-designed drug looks to pass final hurdle, will this tech change drug discovery forever?

AI-led drug for chronic lung disease set to enter phase 3 clinical trials, though experts remain divided on AI’s impact in pharma

Sudhakar Tasgave

‘I barely sleep for four hours’: Are pesticides robbing farmers worldwide of sleep?

Studies point to an emerging link between a range of pesticides and insomnia

Heat map

Chemistry ‘cold spots’ emerging across the UK, RSC warns

Some regions face a future with fewer chemists

Team photo

The startups that grew out of the Pfizer redundancies

18 months on, three former Pfizer employees explain how they’ve seized opportunities to fill gaps in the market

Fighter aircraft

Military demand strains metal supply chains

Conflict and trade disputes have disrupted global supplies of specialist metals like hafnium, antimony and rare earths

Weight loss pills and pen

Will oral weight loss drugs challenge injectables?

Pills may offer convenience for manufacturers, but it’s not clear they will overtake existing drugs

GLP1 Receptors and semaglutide agonists

The challenge of developing oral alternatives to peptide weight loss drugs

Companies are racing to develop alternatives to injectable diabetes and weight loss drugs

A digital artwork of a liposome containing mRNA as used in vaccines

US government cancels mRNA vaccine research

Experts fear industrial and academic research may move abroad after infectious disease projects cancelled

Bee researcher

‘Creative destruction’ in the chemistry lab

Some obsolete lab equipment is quickly replaced, while other items are stubbornly persistent. What modern tech will survive to the 2060s?

DuPont Chamber Works

DuPont and spin-offs settle with New Jersey over PFAS contamination

Proposed deal with the US state includes $875 million in damages, plus clean-up funds

US EPA accused of skewing soil testing data after East Palestine disaster

Environmental Protection Agency will review decisions made during emergency response

Sarepta gene therapy deaths highlight tragic rare disease dilemma

Regulators block Duchenne muscular dystrophy treatment after fatal side-effects outweigh questionable efficacy

China’s drug development charge

Reforms and state support have fuelled domestic and foreign investment in pharmaceutical

EPA will officially dissolve its scientific research arm

Experts warn that closing the Office of Research and Development will hamper efforts to protect the environment and public health

Will HIV prevention get where it’s needed?

Gilead and its partners’ efforts to distribute generic lenacapavir could be derailed by cuts in international aid budgets

Drug production

Ten years on, pharma industry still testing for implausible alkyl sulfonate ester contaminants

Risk assessment for potential mutagenic side-products is still required by regulatory bodies, despite lack of evidence they form during drug production

Refinery

Polymer membrane separates hydrocarbons, offering alternative to distillation

Microporous membrane enables energy efficient chemical separations

Index

Improving propylene synthesis using light-activated catalysis could cut emissions

Single-atom photocatalyst makes propylene at milder temperatures

Generative AI pipeline creates promising antimicrobial peptides

AI model extrapolates beyond training data to predict diverse antimicrobial structures

Far more drugs could be taken orally by formulating them with silica nanoparticles

Many more medicines could be made water soluble making taking them easier for patients

Mapping metabolite disturbances by drugs

High-throughput metabolomic profiling gives insight into unpredictable drug effects

Metal–organic framework captures carbon dioxide at industrially relevant temperatures

Material could improve energy efficiency of capturing carbon from industy’s exhaust gases

Fluorspar to fluorine chemicals without going via hazardous hydrogen fluoride

Safer way to turn calcium fluoride mineral into valuable industrial materials

Liquid spills out of a rusty old barrel

India introduces new rules to tackle chemical contamination sites

New legislation provides a legal framework for assessment and cleanup of 189 named chemicals

Chemours ordered to immediately limit PFAS emissions into Ohio River

US judge grants injunction to reduce Gen-X discharges from West Virginia plant to permitted levels

DuPont and spin-offs settle with New Jersey over PFAS contamination

Proposed deal with the US state includes $875 million in damages, plus clean-up funds

Intergovernmental panel on chemicals, waste and pollution needs diverse input

Balancing industrial expertise against unwanted commercial influence is not easy but shouldn’t be discounted

11 executives jailed over Italian PFAS pollution

Convictions relate to groundwater contamination around Miteni fluorochemicals plant

Military demand strains metal supply chains

Conflict and trade disputes have disrupted global supplies of specialist metals like hafnium, antimony and rare earths

Sanofi

Sanofi to buy Blueprint Medicines for over $9 billion

Blueprint has one approved drug and enhances Sanofi’s immunology portfolio

Merck signage in Darmstadt

Merck KGaA to buy cancer specialist SpringWorks

$3.9 billion deal boosts Merck’s pipeline as it faces patent expiries

Cell culture in laboratory

Optimise drug discovery: predicting transporter-mediated drug interactions

Sponsored by

Learn how in vitro models, biomarkers and modelling can improve prediction of drug interactions and toxicity – reducing false positives and unnecessary clinical studies

Materials analysis concept image from Anton Parr

Pass or fail: rapid polymer analysis with FTIR

Sponsored by

Your guide to quick and reliable verification of polymers with the Lyza 7000 FTIR spectrometer

Sigma-Aldrich SynLED Parallel Photoreactor 2.0

Illuminating progress: recent advances in photoredox catalysis

Sponsored by

In this free download, shed some light on the latest developments in photoredox for drug development and materials science