An anti-HIV vaccine may be closer thanks to a new approach to vaccine design that is being developed.
An anti-HIV vaccine may be closer thanks to a new approach to vaccine design that is being developed at the University of Maryland, US.
Recent studies have found that a new structure based on an oligosaccharide constitutes an epitope on the HIV virus. Medicinal chemists Hengguang Li and Lai-Xu Wang developed a mimic by using modified cholic acid as a rigid scaffold and then attaching oligomannose sugars to it. This scaffold approach has provided a whole new avenue to explore in the design of more effective epitope mimics. The hope is to develop an HIV vaccine based on a carbohydrate.
H Li and L-X Wang, Org. Biomol. Chem., 2004, 2, 483 <MAN>b314565d</MAN>