1,2,3,4,5,6‐hexakis(trifluoromethyl)‐cyclohexane is the most sterically crowded all-cis derivative
A cyclohexane molecule with six trifluoromethyl groups all sitting on the same side of the ring is the most sterically convoluted hexa-substituted cyclohexane ever made. The compound is extraordinarily polar as the ring’s two faces have very different properties: one side is highly electronegative while the other is electropositive.