Two heads are better than one
By 
Derek Lowe2020-02-19T14:27:00
Bifunctionals show that sometimes simply tethering two useful molecules together unlocks some useful activity
There’s been a real surge in drug discovery involving a class of molecules that (for a long time, at least) were considered at best an academic curiosity. These ‘bifunctionals’ are nothing more than two completely different molecules, binding to different targets, that are stitched together with some sort of linking group. That can be as simple as a long alkyl chain, or a short stretch of ethylene glycol ethers, up to as complex a linker as you have the patience to search for.