AdQPhos: Exceptional performance in α-arylation reactions

Palladium-catalysed α-arylation reactions are widely used in the synthesis of pharmaceuticals, agrochemicals and complex organic molecules, but chemists wishing to use these reactions face limitations in substrate scope, operational complexity and environmental sustainability. This free application note reports on a study that shows how AdQPhos, a newly developed adamantylphosphino ferrocene ligand and its palladium precatalysts may address these challenges. The study explores their performance across a broad range of nucleophiles, including amides, esters, ketones, nitriles and nitroalkanes, under both traditional and aqueous conditions. A key focus is on enabling these transformations under milder, greener conditions without compromising efficiency or scalability.

This application note was developed in response to the growing demand for more efficient and greener palladium cross-coupling catalysts. Download now to gain insight into the design and synthesis of AdQPhos and its precatalysts. See how it performs compared to established catalytic systems, while avoiding tedious workups or purification techniques and enabling replacement of toxic or hazardous solvents. This resource will be valuable for chemists seeking more versatile, scalable and environmentally conscious solutions for C–C bond formation.

Download now to:

• Learn how AdQPhos ligands improve the activity of Pd-precatalysts in a range of cross-coupling reactions
• Understand the key benefits of AdQPhos in comparison to traditional ferrocene-based phosphine ligands
• Gain insight into substrate scope and conditions for AdQPhos based α-arylation reactions
• Identify which AdQPhos-Pd systems are most suitable for specific cross-coupling applications
• Gain practical insight into how to implement these catalysts in your own R&D workflows