Optimise cross-coupling with ligand-free NHC–Pd precatalysts

Download now to learn about the synthesis of these precatalysts under mild, scalable conditions and see how the compare to leading commercial alternatives. The application note covers their use in Suzuki–Miyaura, Buchwald–Hartwig and transamidation reactions, showcasing a wide substrate scope and excellent yields – even with challenging aryl chlorides. Whether you’re optimising reaction efficiency or looking for cost effective solutions for large scale processes, this guide provides actionable insights for both research and industrial applications.

Featuring mechanistic studies and real-world performance data, this resource equips you with the knowledge to enhance stability, reduce costs and achieve sustainable scalability in your cross-coupling workflows.

Key insights:

• A unique ligand-free design of NHC–Pd precatalysts 
• Scalable, high-yield synthesis methods
• Comparative performance in key cross-counpling reactions
• Enhanced performance in challenging aryl chloride couplings
• Mechanistic insights into activation pathways and catalytic cycles