Two-in-one reagent combines fluoroalkylation with being click ready

A chemical structure with an N3 and 2 Fs on the first carbon, two Fs and a S O2 Na on the second carbon.

Source: © Petr Beier/Czech Academy of Sciences

Researchers add to growing toolkit of bifunctional reagents

 A new bifunctional reagent allows chemists to install a fluoroalkyl group while simultaneously attaching an azide click handle.1

Click chemistry is a powerful and efficient approach to preparing complex molecules through selective and high yielding reactions that work with many different types of substrates. The classic version combines an azide and an alkyne. However, before chemists can perform such reactions, the molecules they want to join must first have the appropriate functional groups.