Re-engineered psychedelic drug retains therapeutic activity in mice, while limiting negative side effects

Structure diagram of molecules reacting with a protein

Source: © Jason Younkin et al, Science Signaling 2026

Rationally designed molecular structure targets a specific subset of serotonin receptors, and potentially offers a route towards safer psychedelic treatments

A redesigned psychedelic compound retains therapeutic activity while limiting unwanted side-effects during testing on mice. The molecule’s structure was adjusted to avoid interactions with a specific subset of serotonin receptors, potentially offering a blueprint for safer neuropsychiatric drugs.