In the pipeline from Derek Lowe – Page 9
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OpinionCategorising chemists
To the unfamiliar, chemists might all look the same. But some common categories are easy to identify, explains Derek Lowe
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OpinionWho counts as a chemist?
The map of scientific disciplines is growing ever more complex. Derek Lowe surveys the country
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OpinionThe return of the return of natural products
'Natural products are back!' is a headline Derek Lowe has seen several times before
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OpinionThe risk vs reward of drug discovery
Drug discovery is an inherently risky business. Derek Lowe tries to balance some of the risk equations
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OpinionElevating enzymes
Enzymes have been giving chemists inferiority complexes since day one, says Derek Lowe. But there's no denying their potential
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OpinionFluorine fanatics
Some medicinal chemists can't get enough fluorines in their molecules. Derek Lowe explains the love-hate relationship
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OpinionWe need more surprises
Who's that asleep at the back? Don't be too quick to blame yourself when tedious talks and soporific seminars fail to inspire, says Derek Lowe
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OpinionThe 'blockbuster mentality’
Should companies focus on big markets and the blockbuster dream? The more modern approaches are not without risks, says Derek Lowe
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OpinionThe quiet comeback of 'combi-chem'
Derek Lowe investigates the comeback combinatorial chemistry has made in the field of drug discovery
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Opinion
How much selectivity do you want?
Derek Lowe considers the quandaries of living in the age of the kinase
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Opinion
Missing methods
Derek Lowe reminisces about lost laboratory techniques and wonders which will be next to go
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Opinion
If something can’t go on, then it won’t
Derek Lowe looks into his crystal ball to see what the future of medicinal chemistry might be
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OpinionDeath by assay result
Derek Lowe wonders whether tagging molecules with fluorescent labels for assay is like tracking the members of a shoal of fish by tying each one to a whale
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Opinion
How to be an organised scientist
Derek Lowe waxes lyrical about the joys of the electronic lab notebook
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Papers vs patents
Derek Lowe wonders whether peer-reviewed papers or patents are more reliable
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Opinion
The sincerest form of flattery
Is the pharmaceutical industry churning out copycat versions of existing therapies? Derek Lowe dispels a few myths about 'me-too' drugs
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Opinion
Senseless screening
Derek Lowe advises opening your mind during the screening cascade taken by potential drug targets, and remaining goal orientated at all times