All In the pipeline articles – Page 4

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  • 0216CW_Pipeline_630m
    Opinion

    Pride comes before a fall

    2016-02-02T00:00:00Z

    In labs it’s important not to let familiarity breed complacency, says Derek Lowe

  • 0116CW_Pipeline_630m
    Opinion

    The sack race

    2015-12-23T00:00:00Z

    Looking to get fired? Derek Lowe offers some hot tips for a quick exit

  • dictionary
    Opinion

    Emerging from Babel

    2015-11-26T00:00:00Z

    Will English ever lose its place as the lingua franca of chemistry, asks Derek Lowe

  • Martin Shkreli
    Opinion

    What the market will bear?

    2015-09-30T00:00:00Z

    Martin Shkreli’s monopolising model poses some uncomfortable questions for the pharma industry, says Derek Lowe

  • Hot sauce
    Opinion

    Spice up your compounds

    2015-09-25T00:00:00Z

    An occasional foray into uncharted territory is the hot sauce of medicinal chemistry, says Derek Lowe

  • CW0915_Pipeline_630m
    Opinion

    A risky business

    2015-08-28T00:00:00Z

    Graduate research is likely the most risky time of a chemist’s career, says Derek Lowe

  • 0815CW_Pipeline_630m
    Opinion

    A precision instrument?

    2015-07-30T00:00:00Z

    Chemists and biologists have different expectations when it comes to data, says Derek Lowe

  • Arrows missing a target
    Opinion

    Missing the target

    2015-06-23T00:00:00Z

    There are plenty of things that small molecule drugs can’t touch, says Derek Lowe, and it’s not for want of trying

  • 0615CW_Pipeline_630m
    Opinion

    Magic molecule modifiers

    2015-05-29T00:00:00Z

    Late stage functionalisation can seem supernaturally powerful, says Derek Lowe – if you’ve got the nerve to try it

  • CW0515_Pipeline_630m
    Opinion

    Missing mathematics?

    2015-04-29T00:00:00Z

    While you may not need differential calculus every day, mathematics is the basis of scientific thinking, says Derek Lowe

  • CW0415_Pipeline_630m
    Opinion

    Analogues by catalogue

    2015-03-24T00:00:00Z

    Buying in screening compounds directly feels like cutting out the synthetic chemist middleman, says Derek Lowe

  • Computer modelling computer screen
    Opinion

    Tantalising technology

    2015-02-20T00:00:00Z

    Computer-assisted drug design always looks like it’s just about to work, says Derek Lowe, but the reality is complicated

  • 0215CW_Pipeline_300m
    Opinion

    The smell of success

    2015-02-11T00:00:00Z

    Laboratory aromas conjure memories and emotions from elation to a sudden need to vomit, says Derek Lowe

  • CW0115_Pipeline_630m
    Opinion

    Ignorance is no defence

    2015-01-14T00:00:00Z

    In a chemistry lab, what you don’t know really can hurt you, says Derek Lowe

  • CW1214_InthePipeline_630m
    Opinion

    Progress at the pace of the slowest

    2014-12-01T00:00:00Z

    Chemistry is rarely the rate-limiting process in getting a drug to market, says Derek Lowe

  • CW1114_In-the-Pipeline_Fig1_630m
    Opinion

    Chemical space is big. Really big

    2014-10-28T00:00:00Z

    You think it’s a long way to the back of your screening libraries? That’s peanuts to chemical space, says Derek Lowe

  • Presentation of publication garbage truck
    Opinion

    Garbage in, garbage out

    2014-09-29T00:00:00Z

    The rise of low-quality and predatory open access journals and conferences worries Derek Lowe

  • Dusty reagent bottles
    Opinion

    Death of a reagent

    2014-08-22T00:00:00Z

    Fashion and progress combine to mean some reactions and reagents persist, while others fall by the wayside, says Derek Lowe

  • Molecular structure in crystal ball
    Opinion

    The crystal ball that can tell lies

    2014-07-29T00:00:00Z

    X-ray structures are not necessarily definitive, says Derek Lowe, especially when it comes to biomolecules

  • CW0714_Pipeline_630m
    Opinion

    Too big to innovate?

    2014-06-25T00:00:00Z

    How strong is the correlation between company size and research productivity, asks Derek Lowe