In the pipeline from Derek Lowe
Musings on the pharmaceutical industry and aspects of general chemistry from medicinal chemist and blogger, Derek Lowe
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Opinion
Water isn’t normal
Despite its familiarity, water is a chemical oddity. But that’s what makes it fascinating
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Opinion
From one sinking ship to another?
Biogen abandoning Alzheimer’s antibody aducanumab is unusual, but hardly surprising, says Derek Lowe
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Opinion
Saving the sounds of Superstition
Preserving the look, feel and sound of degrading plastic artefacts presents particular problems
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Opinion
Compounding problems
Regulating the line between a vital service and grey-market profiteering is a mess
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Opinion
Slow march of the retrosynthesis robots
Software synthesis suggestions are hampered by biased and incomplete datasets
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Opinion
Surviving in the war of all against all
Cancers and bacteria develop resistance to drugs in remarkably similar ways
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Opinion
Navigating the literature torrent
It’s humanly impossible to filter and read everything worthwhile – let’s embrace assistance
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Opinion
Bringing drug manufacturing back home
Pharmaceutical supply chains are international, complex and opaque. Is there a better way?
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Opinion
Regulators must follow their heads, not their hearts
The 2019 US approval of antibiotic Recarbrio seems not to have met the normally expected standards
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Opinion
Will a court overturn abortion drug’s approval?
Tangle between regulation and politics makes uncomfortable viewing from industry
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Opinion
Meeting the tigers of the lab
Practical teaching strikes a balance between removing hazards and learning to respect them
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Opinion
Turning negative results into positives
Publishing unsuccessful experiments is more important than ever as we try to train machines in chemistry
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Opinion
The psychology of our future with AI
It’s time to accept that digitalisation is changing laboratory work, and embrace the opportunity
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Opinion
Setting drug development speed records
The pandemic treatment sprint was spectacular, but hard to match under less unusual circumstances
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Opinion
Embracing oddities
When new chemistry looks like alchemy or witchcraft, it’s worth taking notice
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Opinion
Nobel vision
Looking beyond the here-and-now let click chemistry open up a whole new world of possibility
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Opinion
Do science courses need hands-on labs to be effective?
The practical lab is where abstract theory connects to physical reality
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Opinion
Why AlphaFold won’t revolutionise drug discovery
Protein structure prediction is a hard problem, but even harder ones remain
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Opinion
May cause side effects
The dose makes the poison, but understanding unwanted drug interactions is complicated