In the pipeline from Derek Lowe – Page 3
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Opinion
From collaboration to collusion
The US government’s crackdown on academics not declaring Chinese funding highlights a moral hazard
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Opinion
Dragons of immunology
Anti-inflammatories like dexamethasone are triumphs amid the pitfalls of the immune system
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Opinion
Does the drug work, or not?
Coronavirus trials reveal the murky reality of disentangling compounds’ effects on human biology
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Opinion
Vaccine development against the clock
How long will it take to develop a coronavirus vaccine and why is it so hard?
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Opinion
Why picking projects is like poker
Sometimes you prefer the high-risk, high-reward project to the ‘sure thing’
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Opinion
Two heads are better than one
Bifunctionals show that sometimes simply tethering two useful molecules together unlocks some useful activity
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Opinion
Reviewing performance reviews
Assessing the value of researchers’ work is hard, but there are some easy ideas to avoid
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Opinion
Will computers ever discover drugs from scratch?
With enough understanding and computing power, it should be possible, but will it happen?
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Opinion
Embracing structural disorder
Medicinal chemists need to overcome their fear of fuzzy proteins
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Opinion
Has x-ray had its day?
Will the giant of structure determination be toppled by blasts from electron beams?
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Opinion
The silent rise of the robots
Mechanical helpers have been creeping into our labs for decades
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Opinion
It's complicated
In a complex world, binary answers are often requested but rarely sufficient
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Opinion
Management by numbers
Reducing intellectual processes to metrics runs the risk of people working to the numbers not the goal
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Opinion
Would you buy synthetic wine?
Can we replicate the chemical profiles of famously expensive drinks? And would people drink them?
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Opinion
We’re going to need a bigger flask
Scaling up reactions is easy to get wrong in a variety of ways
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Opinion
What are the rate-limiting steps in drug discovery?
Getting more drugs to market is not just a chemistry problem
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Opinion
How science shapes our psychology
We learn to embrace the unexpected, follow evidence over opinion and accept that most experiments fail
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Opinion
What would a 1980s student make of modern research?
Nano- and macromolecular science might make for a shocking read in the launderette