All In the pipeline articles – Page 2
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OpinionReverse combustion is preparing for takeoff
Where burning hydrocarbons is unavoidable, creating them from atmospheric carbon is a promising option
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OpinionAll work and no play
Is the long-hours culture of academic organic chemistry laboratories finally changing?
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OpinionWhere are the Covid-19 drugs?
Small molecules appear to be lagging behind development of vaccine and antibody treatments
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OpinionThe price of failure
Drug market structures and high R&D failure rates can tempt companies into bad pricing behaviour
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OpinionPutting combustion into reverse
Unburning carbon dioxide economically and at scale is a tough problem, but potentially world-changing
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OpinionOpening up a cellular black box
Working out how biomolecular condensates work may reveal a lot about the success or failure of different drugs
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OpinionThe side effects of being unique
Even the largest clinical trials won’t capture all possible bad reactions to a drug – we need pharmacovigilance
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OpinionA powerful blow against misconduct
Supporting whistleblowers is vital for detecting and preventing bad behaviour
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OpinionHow the pandemic might change drug research
Derek Lowe muses on some positive lessons learned
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OpinionA rough guide to pharma partnership deals
Coronavirus vaccines are driving unusual collaborations with a range of benefits
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OpinionRuling out the rule of five
Simple calculations for clinical trial success failed to find a winning formula
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OpinionStirring in my sleep
Cut off from the lab after 40 years, Derek Lowe returns to the bench in his dreams
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OpinionThe ins and outs of vaccine trials
Derek Lowe lays out how the trials work, and why they get paused and restarted
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OpinionThe Nobel prize that got binned
Ferrocene is a classic example of a discovery that was dismissed as a failed experiment
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OpinionFrom collaboration to collusion
The US government’s crackdown on academics not declaring Chinese funding highlights a moral hazard
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OpinionDragons of immunology
Anti-inflammatories like dexamethasone are triumphs amid the pitfalls of the immune system
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OpinionDoes the drug work, or not?
Coronavirus trials reveal the murky reality of disentangling compounds’ effects on human biology
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OpinionVaccine development against the clock
How long will it take to develop a coronavirus vaccine and why is it so hard?
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OpinionWhy picking projects is like poker
Sometimes you prefer the high-risk, high-reward project to the ‘sure thing’
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OpinionTwo heads are better than one
Bifunctionals show that sometimes simply tethering two useful molecules together unlocks some useful activity