Biochemistry – Page 2
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Research
Controlling insulin activity in cells with ‘DNA origami’
Insulin–DNA nanorods elicit geometry-dependent insulin activity, which could lead to more targeted treatments for diabetes
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Feature
Battling long Covid with drugs
The challenge of finding drugs for a poorly understood disease with many symptoms is clear. Clare Sansom looks at the work going on to help the people suffering in its shadow
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Opinion
Moving beyond protein structure
Efforts to understand how intrinsically disordered regions interact have produced a variety of answers
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Research
Mutation studies reveal how Antarctic octopus arms itself with cool enzyme
Understanding cold-tolerant enzyme could help with transplant organ preservation
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News
mRNA vaccine pioneers win medicine Nobel prize
Katalin Karikó and Drew Weissman honoured for breakthroughs that enable the rapid development of new vaccines, including several of those used against Covid-19
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Feature
Using DNA evidence to picture suspects
Forensic DNA phenotyping predicts people’s appearance and reveals their ancestry, finds Andy Extance, but has some significant challenges to overcome
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Research
Biochemistry behind CBD’s anti-inflammatory effects points to new ways to treat inflammation
Cell studies unravel mechanism of action but human studies are needed
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Research
Life’s energy currency ATP made using electricity from the grid for the first time
Simplified system uses just four enzymes with socket-supplied electrons replacing biochemical energy
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Feature
The drug developers fighting the antibiotic resistance problem
Andy Extance talks to the researchers innovating across different drug classes in the hunt to develop new treatments
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Feature
Who will pay for new antibiotics?
Governments around the world are starting to consider alternative funding models and incentives for antibiotics. Katrina Megget asks if it is enough
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Feature
Charting the rise in antimicrobial resistance
We look at the data behind antibiotic drug discovery and development, bacterial resistance and the financial problems with the current business model
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Feature
The science behind a ‘runner’s high’
Exercise addicts need to stop talking about getting their endorphin hit, writes Hayley Bennett, and start looking at endocannabinoids
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Research
Molecular fossils solve evolutionary mystery
Fossilised protosteroids confirm Nobel-prizewinner’s decades-old prediction
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Research
Ancient microbial natural products reconstructed from Neanderthal dental plaques
Palaeogenomic approach allows natural product researchers to ‘go back in time’
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Feature
A new generation of materials inspired by teeth
Ian Le Guillou finds that some of nature’s toughest structures are helping scientists to develop new fibres that could revolutionise fabrics
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Research
Orange climbers make fluorescent blue molecules
Naturally occurring aggregation-induced emission luminogens could find use in biomedical imaging
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News
The launch of a new field: precision microbiome editing
Nobel laureate Jennifer Doudna is helping lead a new $70 million project combining metagenomics and CRISPR to solve health, climate problems
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Research
NMR reveals sialic acid biosynthesis in real time
Using NMR, scientists can directly measure sialic acid enzyme conversion velocities for the first time
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Research
Wired-up symbiotic multi-organism can turn sunlight and air into valuable proteins
Symbiont could enable microfactories to produce biochemicals for food, farming and drugs