Biochemistry – Page 3
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FeatureThe proteins that drive drug addiction
Jamie Durrani speaks to researchers exploring how epigenetic changes in the brain affect drug-seeking behaviours
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FeatureWhy don’t we know how antidepressants work yet?
Selective serotonin reuptake inhibitors are at the centre of a collision between social and biochemical outlooks on depression, finds Andy Extance
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FeatureBypassing the blood–brain barrier
Researchers are on a quest to outsmart and overcome the sophisticated security system of the brain. Julia Robinson reports on some of the approaches being studied
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FeatureBrain chemistry basics
Andy Extance looks into the latest in Alzheimer’s disease, pain and memory
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OpinionUnderstanding our brains is complicated, beware of simple ideas
Stepping up from chemistry to complexity
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ResearchNew mechanism identified that is potentially linked to very early stages of Alzheimer’s
Understanding role of fragments of amyloid protein could lead to novel therapies for the disease
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ResearchMicroscopy structures reveal mechanism behind bitter taste
Cryo-EM images provide a detailed picture of bitter taste receptors
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FeatureHow microbes influence our brain health
Our gut microbiome has been linked to conditions such as Parkinson’s and Alzheimer’s. Anthony King reports on the connections
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ResearchDeep learning algorithm predicts structures of biomolecular assemblies
RoseTTAFold extended to predict structures of proteins bound to small molecules
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ResearchEnzyme engineering makes blue denim greener
Environmentally friendlier alternative to indigo dye can now be made at a competitive price
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FeatureSmall molecules that switch up cell development could transform medicine
Turning mature somatic cells back into flexible stem cells using small molecules could revolutionise medicine, especially for regeneration and cancer. Philip Ball reports
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FeatureThe chemistry of love
There’s chemistry behind every step of a romantic relationship, from the initial spark to the pain of break up, as Zahra Khan discovers
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FeatureMore than a mirror-image: left-handed nucleic acids
Now a biological reality, researchers are starting to figure out the many roles of left-handed nucleic acids such as Z-DNA – from immunity to controlling our genetics. Rachel Brazil reports
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ResearchHeavy metals are potential ovarian toxicants
Exposure to metals like arsenic, cadmium and mercury linked to reduced egg production, earlier menopause for middle-aged women
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ResearchD-trypsin synthesis enables sequencing of mirror-image proteins
Reversing the chirality of a protein-digesting enzyme could aid the development of mirror-image therapeutics
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ResearchAutonomous platform engineers enhanced proteins
AI-powered robotic system designs and optimises proteins following its own ‘scientific method’
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ResearchMolecular movie captures DNA repair from start to finish
Study spans pico- to microsecond timescales to uncover enzymatic process
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ResearchUnderwater device reveals marine chemical diversity
I-Smel device probes metabolites produced by Mediterranean sponges
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ResearchPainting with DNA
Fluorescently labeled DNA strands produce a palette of 16 million colours