Biochemistry – Page 4
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ResearchControlling insulin activity in cells with ‘DNA origami’
Insulin–DNA nanorods elicit geometry-dependent insulin activity, which could lead to more targeted treatments for diabetes
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FeatureBattling long Covid with drugs
The challenge of finding drugs for a poorly understood disease with many symptoms is clear. Clare Sansom looks at the work going on to help the people suffering in its shadow
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OpinionMoving beyond protein structure
Efforts to understand how intrinsically disordered regions interact have produced a variety of answers
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ResearchMutation studies reveal how Antarctic octopus arms itself with cool enzyme
Understanding cold-tolerant enzyme could help with transplant organ preservation
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NewsmRNA vaccine pioneers win medicine Nobel prize
Katalin Karikó and Drew Weissman honoured for breakthroughs that enable the rapid development of new vaccines, including several of those used against Covid-19
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FeatureUsing DNA evidence to picture suspects
Forensic DNA phenotyping predicts people’s appearance and reveals their ancestry, finds Andy Extance, but has some significant challenges to overcome
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ResearchBiochemistry behind CBD’s anti-inflammatory effects points to new ways to treat inflammation
Cell studies unravel mechanism of action but human studies are needed
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ResearchLife’s energy currency ATP made using electricity from the grid for the first time
Simplified system uses just four enzymes with socket-supplied electrons replacing biochemical energy
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FeatureThe drug developers fighting the antibiotic resistance problem
Andy Extance talks to the researchers innovating across different drug classes in the hunt to develop new treatments
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FeatureWho will pay for new antibiotics?
Governments around the world are starting to consider alternative funding models and incentives for antibiotics. Katrina Megget asks if it is enough
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FeatureCharting the rise in antimicrobial resistance
We look at the data behind antibiotic drug discovery and development, bacterial resistance and the financial problems with the current business model
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FeatureThe science behind a ‘runner’s high’
Exercise addicts need to stop talking about getting their endorphin hit, writes Hayley Bennett, and start looking at endocannabinoids
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ResearchMolecular fossils solve evolutionary mystery
Fossilised protosteroids confirm Nobel-prizewinner’s decades-old prediction
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ResearchAncient microbial natural products reconstructed from Neanderthal dental plaques
Palaeogenomic approach allows natural product researchers to ‘go back in time’
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FeatureA new generation of materials inspired by teeth
Ian Le Guillou finds that some of nature’s toughest structures are helping scientists to develop new fibres that could revolutionise fabrics
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ResearchOrange climbers make fluorescent blue molecules
Naturally occurring aggregation-induced emission luminogens could find use in biomedical imaging
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NewsThe launch of a new field: precision microbiome editing
Nobel laureate Jennifer Doudna is helping lead a new $70 million project combining metagenomics and CRISPR to solve health, climate problems
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ResearchNMR reveals sialic acid biosynthesis in real time
Using NMR, scientists can directly measure sialic acid enzyme conversion velocities for the first time
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ResearchWired-up symbiotic multi-organism can turn sunlight and air into valuable proteins
Symbiont could enable microfactories to produce biochemicals for food, farming and drugs