Will oral weight loss drugs challenge injectables?

Weight loss pills and pen

Source: © Caroline Ruda/Shutterstock

Pills may offer convenience for manufacturers, but it’s not clear they will overtake existing drugs

Why are companies working so hard to make oral tablet forms of diabetes and weight loss drugs that target the glucagon-like peptide (GLP-1) receptor? The current injectable peptides – Novo Nordisk’s Ozempic and Wegovy (semaglutide) and Eli Lilly’s Mounjaro and Zepbound (tirzepatide) – are incredibly successful, with potentially even more promising peptides in the pipeline. So why the rush to replace them with pills?