Molecular biology – Page 2
-
FeatureHow click conquered chemistry
Katrina Krämer tells the story of how click and bioorthogonal chemistry came to win the 2022 Nobel prize
-
OpinionNobel vision
Looking beyond the here-and-now let click chemistry open up a whole new world of possibility
-
OpinionCracking codons
Understanding how chemistry links RNA triplets to the properties of amino acids
-
OpinionWhy AlphaFold won’t revolutionise drug discovery
Protein structure prediction is a hard problem, but even harder ones remain
-
ResearchTeixobactin’s two pronged antibiotic attack mechanism revealed
Understanding of formation of deadly supramolecular structures could help build improved antimicrobials
-
ResearchMystery of how plants make strychnine solved 75 years after characterisation
Three-quarters of a century after Robinson and Woodward cracked structure chemists unravel poison’s biosynthesis
-
ResearchFossil molecules reveal dinosaurs’ bird-like metabolism
Thioethers preserved in bones show that most dinosaurs were warm-blooded, though T rex may have been particularly sluggish
-
NewsChemistry Nobel laureate Sidney Altman dies at 82
Canadian–American molecular biologist won the 1989 prize for discovering RNA’s catalytic ability
-
ArticleCausal emergence might explain how living systems can operate
Life does not run like clockwork
-
FeatureSequencing one cell at a time
New advances that allow scientists to uncover the molecular differences between individual cells could revolutionise medicine, Ian le Guillou finds
-
ResearchBiochemical secrets of tarantula’s painful bite could point to perfect painkillers
King baboon spider venom could help scientists develop potent analgesics
-
ResearchNew microscope makes tracking chiral molecules in live cells possible
The instrument uses circularly polarised light to tell left- and right-handed species apart and monitor them in space and time
-
ResearchLeft-handed nanoparticles are far better vaccine adjuvants than their mirror images
Chiral gold nanoparticles shown for the first time to elicit differing immune responses in cells and live mice
-
ResearchGel-forming proteins could help tardigrades survive extreme conditions
Biophysical dissection of tardigrade’s disordered protein could uncover how microscopic animals survive conditions that kill most other forms of life
-
ResearchIndividual proteins identified with world’s tiniest ruler
Nanosized caliper that can identify individual proteins could ‘do for proteins what next-generation sequencing did for DNA’
-
ResearchPossible dinosaur DNA discovered in 125-million-year-old fossil
But that doesn’t mean we can clone extinct species Jurassic Park-style
-
ResearchExploiting evolution to explore chemical space shows promise for drug discovery
Using molecular trees – similar to family trees – chemists could predict how products will evolve to make new molecules
-
ResearchDNA robot controls live cells’ movement
Molecular machine walks across cell membrane to activate cellular migration
-
BusinessBrewing up plant-inspired medicines
Antheia reconstructs complex biochemical pathways in yeasts to speed up production of natural product-based drugs
-
ResearchMirror image enzyme constructs longest ever mirror DNA strand
Since chirally inverted DNA is more stable than its natural counterpart, it can be used to encode secret messages