Molecular biology – Page 4
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Research
Antiaromaticity relief mechanism linked to DNA photostability
Textbook organic chemistry concepts bring new understanding to protective biological mechanisms
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Research
Proteins pinpointed in cells at nanometre resolution
Combining fluorescence microscopy and electron tomography will reveal more about how cells work and how diseases disrupt them
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Research
Protein synthesis revolution on way as large peptides made in hours not days
Flow chemistry can now make peptide chains up to 164 amino acids long in one go
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Research
Trapped enzyme reveals its unexpected shape-shifting ability
Metamorphic protein confined in nanopore found to switch between different 3D shapes as it catalyses a redox reaction
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News
Science steps up a gear as struggle to both understand and fight coronavirus intensifies
Research that might have taken years is being turned around in months as journals fast-track Covid-19 manuscripts
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Research
‘Chemical ear defenders’ could prevent hearing loss
Discovery of receptor connected to hearing loss has led to a chemical compound that can protect the neuromechanical machinery in mice’s ears
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Research
First Crispr cancer trial in humans shows safety and durability
Immune-cell modifications target tumours and lift the PD-1 ‘brake’
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Opinion
The chemical absurdity of molecular recognition
Many biological models rely on an agency that molecules lack
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Feature
Can chemists crack our cells’ sugar code?
Rachel Brazil talks to the scientists trying to understand the sweet mystery of the glycome
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Opinion
Richard Henderson: ‘I rejected the phone call, and then noticed it was from Sweden…’
The 2017 laureate tells his story
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Opinion
Chemical computers question the logic of life
Circuits of chemicals could carry out calculations
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Opinion
Embracing structural disorder
Medicinal chemists need to overcome their fear of fuzzy proteins
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Research
Crispr treatment reverses muscular dystrophy in mice
Upregulated gene triggers laminin-α1 protein production, reviving paralysed limbs
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News
International commission launched to tackle tough questions around gene-editing
US and UK scientific academies have convened a new body charged with developing a global framework for heritable human genome editing
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Research
Enzyme evolved to selectively functionalise carbon–hydrogen bonds
Lactam libraries created by engineered bacterial enzyme offer new way to fight antibiotic resistance
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Research
First bacterium with a totally redesigned genome created
Designer E. coli uses a simplified genetic code to make proteins
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Research
Transcription controlled by non-natural DNA modifications
Proof-of-concept for artificial chemical epigenetics
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Research
Harnessing plants and microbes to tackle environmental pollution
Eucharia Nwaichi is using biochemistry to clean up one of the most polluted places on Earth
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Review
Borrowed Time: The Science of How and Why We Age
The field of aging research is still in its infancy
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Research
Leap forward for molecular computing as DNA executes six-bit algorithms
Computer made from DNA strands can recognise palindromes, copy and sort data, and perform random walks