Molecular biology – Page 6
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ResearchFirst Crispr cancer trial in humans shows safety and durability
Immune-cell modifications target tumours and lift the PD-1 ‘brake’
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OpinionThe chemical absurdity of molecular recognition
Many biological models rely on an agency that molecules lack
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Feature
Can chemists crack our cells’ sugar code?
Rachel Brazil talks to the scientists trying to understand the sweet mystery of the glycome
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OpinionRichard Henderson: ‘I rejected the phone call, and then noticed it was from Sweden…’
The 2017 laureate tells his story
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OpinionChemical computers question the logic of life
Circuits of chemicals could carry out calculations
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OpinionEmbracing structural disorder
Medicinal chemists need to overcome their fear of fuzzy proteins
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ResearchCrispr treatment reverses muscular dystrophy in mice
Upregulated gene triggers laminin-α1 protein production, reviving paralysed limbs
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NewsInternational commission launched to tackle tough questions around gene-editing
US and UK scientific academies have convened a new body charged with developing a global framework for heritable human genome editing
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ResearchEnzyme evolved to selectively functionalise carbon–hydrogen bonds
Lactam libraries created by engineered bacterial enzyme offer new way to fight antibiotic resistance
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ResearchFirst bacterium with a totally redesigned genome created
Designer E. coli uses a simplified genetic code to make proteins
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ResearchTranscription controlled by non-natural DNA modifications
Proof-of-concept for artificial chemical epigenetics
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ResearchHarnessing plants and microbes to tackle environmental pollution
Eucharia Nwaichi is using biochemistry to clean up one of the most polluted places on Earth
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ReviewBorrowed Time: The Science of How and Why We Age
The field of aging research is still in its infancy
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ResearchLeap forward for molecular computing as DNA executes six-bit algorithms
Computer made from DNA strands can recognise palindromes, copy and sort data, and perform random walks
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ResearchHole-punching antifungal used as molecular prosthesis for cystic fibrosis
Drug creates artificial ion channels that could replace broken version in cystic fibrosis patients’ lung cells
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NewsLeading geneticists call for worldwide moratorium on creation of gene-edited children
Five-year pause would give nations breathing space following the birth of the first genetically-modified children in November
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ResearchGenes that make lemons sour revealed
When life gives you lemons, mutate their proton pumps to make them sweeter
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ResearchBuilding block approach creates new metalloproteins
Protein modules can be connected by disulfide linkages while varying the metal ions
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ResearchEight-letter genetic code hints at how alien life might evolve
Synthetic DNA shows that four bases might not be the only way for life to go
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PodcastMelarsoprol
Cases of sleeping sickness – human African trypanosomiasis – are in decline, dropping 86% in Africa between 2000 and 2014. Gege Li explores the role that this toxic, arsenic-based medication has to play.
