Drug formulation and delivery
The latest chemistry news and research on drug formulation and delivery, including encapsulation, controlled release and nanomedicine, from the Royal Society of Chemistry's magazine, Chemistry World
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ResearchNanocomplex becomes a master of shape-shifting to target tumour cells
Switching from nanofibres in the blood to virus-like particles in a tumour environment brings drugs to where they are needed
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WebinarModelling amorphous solid dispersion (ASD) release mechanisms
Learn how thermodynamic modelling and molecular simulation can help our understanding of amorphous solid dispersion
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FeatureManaging the menopause
The end of ovulation will affect almost all women, but current treatments could be improved. Rachel Brazil reports on the efforts to find a better solution
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Research3D printing deep in the body using ultrasound could deliver drugs, heal wounds
Biocompatible inks allowed polymers to be printed in animals without harming them
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ResearchGlycoconjugate-caged drugs offer better way to treat inflammatory bowel disease
Plant fibres trap drugs, only releasing them in the lower intestine where they are more effective
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BusinessAcceptable levels of (epi)genetic engineering
Amplifying or silencing genes may be preferable to permanently changing genetic code
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BusinessEpigenetic editors enter clinical trials
New wave of precision medicines amplify or silence genes, without altering genetic code
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BusinessEnding of US weight-loss drug shortages prompts compounder complaints
Decision ends pharmacies’ permission to prepare versions of GLP-1 hormone mimics
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OpinionHow natural nanomotors could propel new drug delivery systems
Biological cells including bacteria, sperm cells and microalgae show promise for precision treatments
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ResearchFar more drugs could be taken orally by formulating them with silica nanoparticles
Many more medicines could be made water soluble making taking them easier for patients
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WebinarHarnessing hormones for health: Taking GLP-1 from research to reality
Learn about the groundbreaking science research behind the GLP-1 revolution
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ResearchTherapeutic proteins can hitch a ride on parasite to bypass blood-brain barrier
Toxoplasma could be delivery agent for protein drugs – provided parasite can be made safe
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ResearchDrugs and vaccines could be freed from cold chains by hydrogel
Stiff gel prevents proteins from aggregating, preserving their therapeutic power
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ResearchCould mechanochemistry have saved Abbott Laboratories $250 million?
Ball milling solves problem of disappearing ritonavir polymorph
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BusinessNovo Holdings to buy contract manufacturer Catalent for $16.5 billion
Parent firm will then sell on three manufacturing sites to Novo Nordisk to boost capacity for diabetes and weight loss drugs
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ResearchAntibiotic adjuvant designed to subvert bacterial defence mechanisms
Amphiphilic molecule helps obsolete antibiotics accumulate and act within bacteria
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OpinionCompounding problems
Regulating the line between a vital service and grey-market profiteering is a mess
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ResearchNew insights into polyamorphism could influence how drugs are formulated
Findings suggest dihedral angle distribution might explain why polyamorphs have different physical properties
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BusinessUK becomes first country in the world to authorise a Crispr-based gene therapy
Treatment aims to cure patients with β-thalassaemia and sickle-cell disease