Medicinal chemistry – Page 3
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Business
US industry braced for change as election looms
Regulation, trade tariffs and innovation support top lists of concerns
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Opinion
Being wrong is almost inevitable
On the tightrope of expressing your opinion, you always risk looking a fool
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Opinion
GLP-1 drugs could be more than a win–win for weight loss
Semaglutide and tirzepatide are changing lives, and could change our attitudes
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Feature
The GLP-1 weight loss revolution
Glucagon-like peptide-1 agonist drugs, such as semaglutide, could save countless lives at risk due to diabetes and obesity. Rachel Brazil looks at the difficulties in making the peptides themselves, and what’s coming next
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Opinion
Proteins’ shape and function are two sides of the same coin
A new perspective on the relationship between chemistry and biology
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Business
MDMA rejection poses questions for psychedelic drug trials
Decision prompts reflection over how psychotherapy is involved, regulating combination treatments and safeguarding patients
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Research
Potential new class of antibiotics takes on flesh-eating infections
Peptide-mimicking compounds target bacterial cell walls
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Research
Innovative antibacterial strategy shows promise for treating infections
New antibiotic mechanism sees molecule infiltrate bacterial cells and destroy them from the inside
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Research
Analytical chemistry tools point to the future of personalised medical diagnostics
Molecular fingerprinting techniques outperform standard blood tests for detecting the onset of many diseases
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Opinion
Medicinal chemistry’s biological blind spots
Despite advances in modern medicine, there are some big gaps in our knowledge
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Research
Therapeutic proteins can hitch a ride on parasite to bypass blood-brain barrier
Toxoplasma could be delivery agent for protein drugs – provided parasite can be made safe
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Business
Weight-loss drugmakers bet billions on boosting supplies
Eli Lilly and Novo Nordisk invest to expand in-house manufacturing of GLP-1 drugs
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Research
Drugs and vaccines could be freed from cold chains by hydrogel
Stiff gel prevents proteins from aggregating, preserving their therapeutic power
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Research
Nanopore proteins designed from scratch and turned into biosensors
Artificial ion channels used to detect disease indicators and pharmaceuticals
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Research
Companion compound for naloxone could boost opioid reversal effects, save lives
Discovery could help in fight against super-strength opioids such as fentanyl
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Opinion
Understanding our brains is complicated, beware of simple ideas
Stepping up from chemistry to complexity
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Feature
Bypassing the blood–brain barrier
Researchers are on a quest to outsmart and overcome the sophisticated security system of the brain. Julia Robinson reports on some of the approaches being studied
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Feature
Why don’t we know how antidepressants work yet?
Selective serotonin reuptake inhibitors are at the centre of a collision between social and biochemical outlooks on depression, finds Andy Extance
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Feature
The high price of a suntan
Skin cancer is on the rise in many countries around the world, but so are the methods to treat it. Bárbara Pinho reports
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Business
Moderna’s mRNA vaccine approved for RSV
US approval adds complementary option to protein-based vaccines for respiratory syncytial virus