Medicinal chemistry – Page 3
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CareersHow Bathabile Ramalapa is making a place for chemistry in health innovation
The award-winning scientist is solving health problems in the global south and inspiring other girls to follow suit
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OpinionWomen are not just another confounding factor in drug development
Ignoring physiological differences between the sexes is indefensible
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Research3D printing deep in the body using ultrasound could deliver drugs, heal wounds
Biocompatible inks allowed polymers to be printed in animals without harming them
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ResearchGlycoconjugate-caged drugs offer better way to treat inflammatory bowel disease
Plant fibres trap drugs, only releasing them in the lower intestine where they are more effective
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ResearchAccelerating chemical discovery through high-throughput experimentation: in conversation with Matthew Gaunt
Professor Matthew Gaunt from the University of Cambridge shares his thoughts on HTE and the role of automation and computational models in discovering new chemical space.
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OpinionIn search of truth and rules
To codify and predict ever more complex phenomena is one of science’s great drivers
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BusinessMerck KGaA to buy cancer specialist SpringWorks
$3.9 billion deal boosts Merck’s pipeline as it faces patent expiries
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ResearchLSD analogue synthesised by swapping just two atoms less likely to cause hallucinations
New molecule shows promise for treating neuropsychiatric conditions such as schizophrenia
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WhitepaperOptimise drug discovery: predicting transporter-mediated drug interactions
Learn how in vitro models, biomarkers and modelling can improve prediction of drug interactions and toxicity – reducing false positives and unnecessary clinical studies
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ResearchGraphene-enhanced supramolecular gels direct how drug molecules crystallise
System could be useful in preformulation stage of drug development
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ResearchCascade reaction brings a new dimension to amine synthesis
Method creates two new rings and four new bonds
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ResearchSimple blood test could enable detection of Parkinson’s disease before symptoms emerge
Test on tRNA fragment ratios shows promise
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NewsFears grow over the future of mRNA vaccine research in the US
Researchers working on mRNA vaccines fear federal funding might be halted, with many looking to move projects abroad
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BusinessAcceptable levels of (epi)genetic engineering
Amplifying or silencing genes may be preferable to permanently changing genetic code
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ResearchRare disease drug can make human blood toxic to mosquitoes
Insect enzyme inhibitor could help control malaria
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BusinessEpigenetic editors enter clinical trials
New wave of precision medicines amplify or silence genes, without altering genetic code
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BusinessUS regulatory chief’s resignation raises alarms in biotech industry
FDA vaccines and biologicals centre director, Peter Marks, clashed with health secretary Robert F Kennedy Jr
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OpinionWelcome to the MegaPharm target selection and project resourcing meeting
Overheard recently in a seminar room near you…
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OpinionWeight loss drug supply races
With official shortages ended, but the first generics gearing up for launch, companies are looking for the next generation of drugs
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ResearchSkeletal editing targets double bonds
Two new techniques selectively install nitrogen atoms into complex molecules