All Medicinal chemistry articles – Page 4
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ResearchSmall molecule finds flu virus’s weak spot
Drug candidate that targets highly conserved region of virus gave mice complete protection from swine flu
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Feature
The battle to lose weight
Losing weight – and not putting it back on – is about much more than willpower. Nina Notman reports on the drugs trying to penetrate the complex metabolic web of hunger and satiety.
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Research
Cracking enzyme structure offers new way to treat rare heart diseases
Solution was found by combining protein with its chaperone
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Research
Genetically engineered yeast brews up heady mix of natural and unnatural cannabinoids
Biotech yeast makes low-cost, high-quality THC and CBD – and cannabinoids never seen before – without growing cannabis plants
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Research
The five reactions on every organic chemist’s wish list
Synthesis has some catching-up to do to create the reactions every drug discovery chemist dreams of
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News
Personalised medicine has failed to live up to the hype, researchers claim
Predictions that Human Genome Project would usher in an era of tailored therapies have largely failed to come true
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Opinion
How teenagers are disrupting drug discovery
A citizen science project to improve access to malaria drugs
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Research
Alzheimer’s linked to infection of the brain by gum disease bacterium
Drug firm is developing treatment to inhibit bacterial enzymes believed to be damaging important protein
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Research
Screening strategy pursues photocatalytic couplings for drug discovery
High-throughput screening and flow-based scale-up combo identifies chemistry needed to functionalise drug fragments and obtain useful amounts of product
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Research
Patent-busting AI tool navigates around protected drug pathways
Organic retrosynthesis software can identify key bonds involved in patented reactions to find alternative pathways
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Opinion
What are the rate-limiting steps in drug discovery?
Getting more drugs to market is not just a chemistry problem
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Research
Crowdsourced drug discovery pits half-forgotten compounds against neglected diseases
45 research groups donate 350 compounds to the first crowdsourced screening library
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Podcast
Ellagic acid
Louise Crane introduces the antioxidant that led to exaggerated claims that 'whisky helps fight cancer'
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Research
Blood pressure drug reacts with membrane lipids
Lipidation products add to evidence that biological membranes are far from chemically inert
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Research
Nanodecoys lure and trap Zika virus
Gelatin nanoparticles camouflaged by mosquito membrane mop up virus and stop it crossing placenta
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Research
Self-powered cancer therapy triple whammy
Diagnosis, drug delivery and effectiveness monitoring combination could realise precision cancer therapy
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Research
Double umpolung approach to amino amide synthesis
Unusual disconnection strategy behind stereocontrolled route to β-amino amides
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Research
Erythropoietin benefits from controlled sugar-coating
Click chemistry allows glycosylation at virtually any synthetic stage
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Business
Sartan drug contamination brings cancer uncertainty
Levels of nitrosamines and other carcinogens in affected tablets of valsartan and related drugs similar to smoking 20 cigarettes a day
