All Medicinal chemistry articles – Page 4
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NewsPersonalised medicine has failed to live up to the hype, researchers claim
Predictions that Human Genome Project would usher in an era of tailored therapies have largely failed to come true
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Opinion
How teenagers are disrupting drug discovery
A citizen science project to improve access to malaria drugs
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Research
Alzheimer’s linked to infection of the brain by gum disease bacterium
Drug firm is developing treatment to inhibit bacterial enzymes believed to be damaging important protein
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Research
Screening strategy pursues photocatalytic couplings for drug discovery
High-throughput screening and flow-based scale-up combo identifies chemistry needed to functionalise drug fragments and obtain useful amounts of product
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Research
Patent-busting AI tool navigates around protected drug pathways
Organic retrosynthesis software can identify key bonds involved in patented reactions to find alternative pathways
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Opinion
What are the rate-limiting steps in drug discovery?
Getting more drugs to market is not just a chemistry problem
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Research
Crowdsourced drug discovery pits half-forgotten compounds against neglected diseases
45 research groups donate 350 compounds to the first crowdsourced screening library
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Podcast
Ellagic acid
Louise Crane introduces the antioxidant that led to exaggerated claims that 'whisky helps fight cancer'
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Research
Blood pressure drug reacts with membrane lipids
Lipidation products add to evidence that biological membranes are far from chemically inert
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Research
Nanodecoys lure and trap Zika virus
Gelatin nanoparticles camouflaged by mosquito membrane mop up virus and stop it crossing placenta
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Research
Self-powered cancer therapy triple whammy
Diagnosis, drug delivery and effectiveness monitoring combination could realise precision cancer therapy
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Research
Double umpolung approach to amino amide synthesis
Unusual disconnection strategy behind stereocontrolled route to β-amino amides
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Research
Erythropoietin benefits from controlled sugar-coating
Click chemistry allows glycosylation at virtually any synthetic stage
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Business
Sartan drug contamination brings cancer uncertainty
Levels of nitrosamines and other carcinogens in affected tablets of valsartan and related drugs similar to smoking 20 cigarettes a day
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Business
Breaking the silence of RNA interference drugs
A wave of treatments is set to follow the first approval of an RNAi therapy
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Research
Scorpion venom peptide engineered to sting brain disorders
Structure used to escort nanoparticles across blood–brain barrier also resists protease degradation
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Review
Bitter Pills: The Global War on Counterfeit Drugs
Muhammad Zaman’s book gives an account of the challenges facing drug regulators worldwide
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Review
How to Change Your Mind: The New Science of Psychedelics
Journalist Michael Pollan’s 9th book is a fascinating history of psychedelic drugs.
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Research
Hidden gene cluster unearthed to reveal antibacterial natural product
Scientists encourage soil microorganisms to express themselves
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Podcast
Furanocoumarin
Florence Schechter discovers how a seemingly healthy grapefruit-based breakfast could disrupt your daily drugs
