Medicinal chemistry – Page 4
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FeatureCharting the rise in antimicrobial resistance
We look at the data behind antibiotic drug discovery and development, bacterial resistance and the financial problems with the current business model
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ResearchMapping antibiotic’s binding of its target points to way to give drugs the killer edge
Technique that creates a comprehensive catalogue of mutations in antibiotic’s target reveals how drugs might be improved
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ResearchFinger sweat test shows promise for checking that patients are taking antipsychotics
Mass spectroscopy test can distinguish between those who have handled drugs and those who have taken them
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ResearchSynthetic peptide mimics can act as antivirals
Peptoids disrupt enveloped viruses’ lipid membranes as well as targeting fungi and bacteria
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ResearchRevived Neanderthal and Denisovan peptides show antibiotic activity
Molecular-scale ‘Jurassic Park’ process could uncover new medicines
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OpinionCould cheap CRO rates threaten to destabilise biotech?
Pharmaceutical pipelines are heavily dependent on contract research organisations; we can’t afford for them to fail
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ResearchCopper catalyst behind general strategy for synthesising methylenecyclobutane compounds
Simple method that produces strained and synthetically-demanding molecules could be a boon for medicinal chemists
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ResearchClick chemistry offers new, efficient process to produce unique cancer-fighting antibodies
Chemical approach is fast and flexible and could be an alternative o using protein engineering
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ResearchTell-tale protein fragment discovered in Alzheimer’s patients could be basis for blood test
Tau protein fragment could track progress of the disease
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NewsAustralia greenlights psychedelics for depression while UK research falls further behind
MDMA and psilocybin are to be offered to be patients suffering from intractable mental health conditions
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OpinionWho knew what? And when?
Finding the line between commercially sensitive information and public and environmental protection
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BusinessRevolutionising RSV prevention
New vaccines and a long-acting antibody aim to protect older adults and babies from respiratory syncytial virus
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ArticleLight-activated molecular motor drives drug delivery
Drug-delivery system is a ‘step towards using molecular motors in the clinic’
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ResearchAI can suggest Covid-19 antivirals from protein sequence alone
IBM model can also find molecules that bind at different sites on target proteins
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ResearchLateral flow HPV test could increase detection rates in resource-poor settings
Low-cost assay works uses self-collected samples and gives results within 45 minutes
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CareersWorking at the forefront of AI
Petrina Kamya’s curiosity has led her across sectors to become a leader in drug discovery
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ResearchBiocatalytic process shows promise for large-scale medicinal oligonucleotide production
Promising nucleic acid therapies could be made more cheaply, greenly and simply
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OpinionBringing drug manufacturing back home
Pharmaceutical supply chains are international, complex and opaque. Is there a better way?
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FeatureMaking replacement organs
From iron lungs to smartphone-controlled insulin pumps, Clare Sansom looks at the efforts to create artificial organs