All Medicinal chemistry articles – Page 4
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ResearchCommon inactive drug ingredients not as inert as thought
38 out of 639 excipients tested interact with toxicity-related proteins, some reaching levels that might produce unwanted effects
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Opinion
Looking beyond the next wave
We need to apply lessons from Covid-19 to tackle antimicrobial resistance and climate change
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Business
What are the risks of fast-tracking a Covid-19 vaccine?
Condensing timelines from years to months inevitably involves compromises
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Opinion
Ghanaian biochemistry TV star Marian Addy
Marian Addy was the first female science professor in Ghana, who studied herbal medicine – and was a TV star
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Sponsored
Collaborative chemistry
Welcome to our collaborative chemistry collection, which shows collaborations creating a more connected tomorrow as challenges in science and industry increase
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Business
Scrambling and gambling to scale up Covid-19 medicines
Organisations work towards making billions of doses of products not yet proven to work
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Opinion
Dragons of immunology
Anti-inflammatories like dexamethasone are triumphs amid the pitfalls of the immune system
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Research
Unprecedented biosynthetic transformation found to connect antibacterial polyketides from ant microbiome
Study identifies enzymes that convert flat fasamycins into three-dimensional formicamycins
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Research
Algorithm devises synthetic contingency plans for Covid-19 drug
Retrosynthesis software tool can identify multiple synthetic routes that use inexpensive and diverse starting materials while avoiding patented methods
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Feature
The difficulties of drugging our brains
Following the withdrawal of many large pharma companies from central nervous system research, Andy Extance finds new drug development patterns are emerging
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Podcast
Cimetidine
Mike Freemantle introduces the peptic ulcer treatment cimetidine, which – as Tagamet – became the first blockbuster drug
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Research
Method that yields oxygen-18-enriched alcohols set to bolster drug studies
Mitsunobu-based protocol is simple alternative to limited and lengthy methods
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Podcast
Fexinidazole
The World Health Organisation hope to eradicate sleeping sickness within our lifetimes. Jamie Durrani looks at a drug that may make it possible.
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Research
Database offers another way to search for drugs – by activity not structure
Dataset offers new way for biomedical researchers to identify potential drug candidates
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Opinion
Covid-19 poses trust issues for science
The pandemic is proving the importance of public trust in science
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Podcast
DMT – Dimethyltryptamine
Georgia Mills investigates the psychoactive found in ayahuasca that may mirror near-death experiences
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Business
How Covid-19 is changing drug manufacturing
Catalent is adapting, focusing on employee safety and supply chain security
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Business
This little Crispr went to market
Gene editing technology heading towards commercial reality in pharmaceuticals, food and organ transplant
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Opinion
Alice Ball’s treatment for leprosy
Nina Notman tells the overlooked story of historic African-American chemist Alice Ball who developed the first partially-effective treatment for leprosy
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Opinion
Hopes and fears for remdesivir
Available resources for testing coronavirus treatments need to be used wisely
