All Medicinal chemistry articles – Page 5
View all stories with this category.
-
ResearchChemists complete synthesis of molecule ‘at the limits of complexity’
Synthesis of canataxpropellane paves the way to biological studies
-
Research
First Crispr cancer trial in humans shows safety and durability
Immune-cell modifications target tumours and lift the PD-1 ‘brake’
-
Research
Warning that 3D printing pills can stop drugs working
Photoreactive monomers need close scrutiny for production of polypills
-
Feature
The search for cancer vaccines
Claire Jarvis looks at ongoing work to prevent the disease – and convince a sceptical community of their seriousness
-
Business
Cancer and rare diseases dominated 2019 drug approvals
More streamlined review processes and changing R&D priorities have contributed to sustained increase in new medicines
-
Business
Researchers call for stricter rules on drug-like medical devices
More oversight is needed over products in the grey area between medical device and medication
-
Opinion
Startup EQRx claims it can revolutionise drug discovery
If it can deliver reasonable drugs at knock-down prices, will providers be convinced?
-
Research
Sugars designed to disrupt bacterial cell wall biosynthesis
Rare monosaccharides explore concept for new narrow-spectrum antibiotics
-
Research
Synthetic strategy exploits fluxional nitrogen to deliver three chiral centres for the price of one
Innovative method amplifies chirality and complexity in medicinally relevant cyclic hydrazines
-
Business
Revived Alzheimer’s antibody met with guarded optimism
Biogen’s aducanumab offers the possibility to slow disease progress, but regulators will likely want more convincing evidence
-
Research
Compact pharmaceutical factory manufactures drugs on demand
Plant with modular design would occupy about half the area of a squash court
-
Research
Inorganic fragment library ready to help drug discoverers reach neglected regions of chemical space
A new approach to fragment-based drug design
-
Podcast
Iminosugars
After some promising results treating ill pets, some researchers think iminosugars could become treatments for infection and even cancer. Mike Freemantle explores the buzz around iminohoney
-
Business
Pharmaceuticals roundup 2019
Under the shadow of political turmoil and major lawsuits, the industry returned to its strengths – making new drugs, and finding new ways to do it better
-
Research
Engineered insulin with enhanced thermal stability inspired by fish-hunting snails
Four-disulfide insulin has similar bioactivity to native human insulin
-
News
European commission gives green light to first Ebola vaccine
Drug shown to be effective and safe following clinical trials involving 16,000 people
-
Research
Flow synthesis produces chiral intermediate for antidepressant drug
The first solvent-free organocatalytic flow process yields the key chiral intermediate for paroxetine on a multigram-scale
-
-
Opinion
Will computers ever discover drugs from scratch?
With enough understanding and computing power, it should be possible, but will it happen?
-
News
Study claiming gene-edited babies were more likely to die young was wrong
Database bias introduced major error in a now retracted study on Crispr babies’ mortality
