Medicinal chemistry – Page 5
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Research
Underwater device reveals marine chemical diversity
I-Smel device probes metabolites produced by Mediterranean sponges
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Business
Three US juries side with cancer victims over Bayer on Roundup
Bayer unit Monsanto has lost its ‘winning streak’ of nine defence verdicts, and the company plans to appeal
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Research
Controlling insulin activity in cells with ‘DNA origami’
Insulin–DNA nanorods elicit geometry-dependent insulin activity, which could lead to more targeted treatments for diabetes
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Feature
Battling long Covid with drugs
The challenge of finding drugs for a poorly understood disease with many symptoms is clear. Clare Sansom looks at the work going on to help the people suffering in its shadow
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Research
Genetic-editing of chickens protects them from catching the flu
Approach heralds new way to make animals resistant to disease
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Opinion
Moving beyond protein structure
Efforts to understand how intrinsically disordered regions interact have produced a variety of answers
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Opinion
Letters: October 2023
Readers discuss antibiotic challenges, muse about micrographs and remember Philip Eaton
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Business
US regulator says phenylephrine is ineffective as a decongestant
FDA will begin consultation on removing the drug from hundreds of over-the-counter remedies
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News
mRNA vaccine pioneers win medicine Nobel prize
Katalin Karikó and Drew Weissman honoured for breakthroughs that enable the rapid development of new vaccines, including several of those used against Covid-19
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Business
Addressing the saga of nitrosamine contamination in drugs
Scientific and regulatory progress is helping minimise the impact of mutagenic impurities
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Research
Transformation analysis reveals structural similarities in FDA-approved drugs
Reaction informatics tools combined to create a new method for mapping chemical space
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News
Europeans’ BPA exposure still exceeds safety threshold but levels may be starting to fall
Europe’s environment agency finds that BPA levels in the urine of 92% of adults from 11 European nations exceeds safe limit
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Business
Positive trial sets stage for therapeutic use of MDMA in US
Hallucinogen-assisted psychiatric treatment heads to regulators, amid cost and other concerns
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Business
Tornado at Pfizer plant accentuates US drug shortage issues
Perennial problem will not be addressed without major reforms to drug market
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Research
Biochemistry behind CBD’s anti-inflammatory effects points to new ways to treat inflammation
Cell studies unravel mechanism of action but human studies are needed
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Feature
The drug developers fighting the antibiotic resistance problem
Andy Extance talks to the researchers innovating across different drug classes in the hunt to develop new treatments
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Business
How can we maintain the effectiveness of existing antimicrobials?
Reducing environmental pollution and tackling quality issues to stave off resistance