All Medicinal chemistry articles – Page 5
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BusinessBreaking the silence of RNA interference drugs
A wave of treatments is set to follow the first approval of an RNAi therapy
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Research
Scorpion venom peptide engineered to sting brain disorders
Structure used to escort nanoparticles across blood–brain barrier also resists protease degradation
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Review
Bitter Pills: The Global War on Counterfeit Drugs
Muhammad Zaman’s book gives an account of the challenges facing drug regulators worldwide
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Review
How to Change Your Mind: The New Science of Psychedelics
Journalist Michael Pollan’s 9th book is a fascinating history of psychedelic drugs.
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Research
Hidden gene cluster unearthed to reveal antibacterial natural product
Scientists encourage soil microorganisms to express themselves
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Podcast
Furanocoumarin
Florence Schechter discovers how a seemingly healthy grapefruit-based breakfast could disrupt your daily drugs
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Research
First oral antibiotic booster for four decades could tackle drug resistance
Sulfate-masking strategy makes bacterial enzyme inhibitor an easy pill to swallow
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Opinion
Passing through checkpoints
A new breed of cancer treatments highlights what’s possible when industry concentrates its efforts
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Research
New peptide destroys Zika virus in brain for first time
Engineered molecule ruptures virus particles to tackle infection
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Business
Cancer immunotherapy spreads rapidly
New approvals and expanded use for checkpoint inhibitor drugs illustrate the power of Nobel-winning science
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Opinion
The projects drug companies wish they’d never started
Failures are common in drug research, but some are bigger than others
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Research
Nanoparticles offer extensive new cure for snakebites
Treatment neutralises venom, reducing tissue damage
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Business
Cleaning up clinical trials
Campaigns to enforce complete and correct reporting of trial data are beginning to take hold
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News
What is directed evolution and why did it win the chemistry Nobel prize?
If you’ve got questions about yesterday’s chemistry Nobel prize then we’ve got answers
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News
What is 'checkpoint therapy' and why did it win the medicine Nobel prize?
James Allison and Tasuku Honjo released the ‘brakes’ on our immune system to combat cancer
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News
Immune-stimulating cancer treatment takes 2018 medicine Nobel
James Allison and Tasuku Honjo receive science’s highest honour for discovering how cancer stops immune cells from attacking
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Research
Exotic amino acids made easy with radicals
Stereoselective radical coupling to rival classic Strecker synthesis for easy access to unusual amino acids
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Business
Landmark China cancer drug full approval ‘first of a wave’
Chi-Med’s fruquintinib is a result of China’s evolving drug innovation and regulation
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Feature
The nuclear option
Using radioisotopes to image inside patients’ bodies – nuclear medicine – is under threat from ageing reactors. James Mitchell Crow discovers the new science trying to fix the problem
