All Medicinal chemistry articles – Page 5
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ResearchHidden gene cluster unearthed to reveal antibacterial natural product
Scientists encourage soil microorganisms to express themselves
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Podcast
Furanocoumarin
Florence Schechter discovers how a seemingly healthy grapefruit-based breakfast could disrupt your daily drugs
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Research
First oral antibiotic booster for four decades could tackle drug resistance
Sulfate-masking strategy makes bacterial enzyme inhibitor an easy pill to swallow
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Opinion
Passing through checkpoints
A new breed of cancer treatments highlights what’s possible when industry concentrates its efforts
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Research
New peptide destroys Zika virus in brain for first time
Engineered molecule ruptures virus particles to tackle infection
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Business
Cancer immunotherapy spreads rapidly
New approvals and expanded use for checkpoint inhibitor drugs illustrate the power of Nobel-winning science
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Opinion
The projects drug companies wish they’d never started
Failures are common in drug research, but some are bigger than others
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Research
Nanoparticles offer extensive new cure for snakebites
Treatment neutralises venom, reducing tissue damage
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Business
Cleaning up clinical trials
Campaigns to enforce complete and correct reporting of trial data are beginning to take hold
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News
What is directed evolution and why did it win the chemistry Nobel prize?
If you’ve got questions about yesterday’s chemistry Nobel prize then we’ve got answers
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News
What is 'checkpoint therapy' and why did it win the medicine Nobel prize?
James Allison and Tasuku Honjo released the ‘brakes’ on our immune system to combat cancer
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News
Immune-stimulating cancer treatment takes 2018 medicine Nobel
James Allison and Tasuku Honjo receive science’s highest honour for discovering how cancer stops immune cells from attacking
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Research
Exotic amino acids made easy with radicals
Stereoselective radical coupling to rival classic Strecker synthesis for easy access to unusual amino acids
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Business
Landmark China cancer drug full approval ‘first of a wave’
Chi-Med’s fruquintinib is a result of China’s evolving drug innovation and regulation
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Feature
The nuclear option
Using radioisotopes to image inside patients’ bodies – nuclear medicine – is under threat from ageing reactors. James Mitchell Crow discovers the new science trying to fix the problem
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Research
Hepatitis C drug lead designed to target virus RNA
Gene-to-RNA-to-medicine pipeline possible thanks to technique that reveals interactions between RNA and small molecules
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Research
Genentech antibiotic quells resistance
Modified arylomycin combines high potency with new mechanism of action
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Opinion
Feeding the confusion
When it comes to working out what foods do to our bodies, mostly we just don’t know
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Feature
The quest to cure HIV
Although HIV–Aids can now be managed quite well with antiretroviral drugs, there is still no cure. Anthony King talks to the scientists trying to find one
