Medicinal chemistry – Page 5
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OpinionBringing drug manufacturing back home
Pharmaceutical supply chains are international, complex and opaque. Is there a better way?
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FeatureMaking replacement organs
From iron lungs to smartphone-controlled insulin pumps, Clare Sansom looks at the efforts to create artificial organs
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BusinessThe diabetes drugs aiming to aid weight loss
Can peptide hormone mimics avoid the side effect pitfalls of previous weight loss treatments?
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BusinessUS supreme court confirms Amgen’s cholesterol antibody patents invalid
Decision could mean patent descriptions need to be even more detailed, and hence expensive
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ResearchRisk of developing rheumatoid arthritis doubled by polycyclic aromatic hydrocarbons exposure
Study examined link between PAHs, phthalates, plasticisers and smoking and the condition
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WebinarBuilding organisational consensus around the tools of digital chemistry
Learn how change agents at Johnson Matthey developed a coalition of support for data-driven science
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NewsOverlooked documents shed new light on double helix discovery
Rosalind Franklin was more than just a ‘wronged heroine’
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NewsIndustry awaits decision on BPA as EU health bodies disagree on safe levels
European Food Safety Authority recommends 20,000-fold reduction in BPA levels
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BusinessMerck & Co to buy immunology specialist Prometheus
$10.8 billion cash deal give Merck rights to late-stage candidate for two inflammatory bowel conditions
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BusinessGhana and Nigeria approve Oxford malaria vaccine
Approval comes before final-stage clinical trials have been completed
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ResearchMechanochemically accelerated sublimations used to separate chiral molecules
New technique combines ball milling with NMR to monitor sublimations in real time
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NewsAfrica plans a network of genomics centres of excellence to tackle disease
Proposed $200 million programme to improve continent’s health would begin with two pilot centres
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ResearchSoapbark tree’s biosynthetic pathway for vaccine adjuvant saponins
Researchers use genome mining and bioengineering techniques to map out route
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NewsAir jet gun delivers needle-free vaccines in MOFs without any need for refrigeration
Release rate of injector system can be fine-tuned by changing the carrier gas
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OpinionThe toxic nature of yew, the tree of the dead
Historically associated with resurrection, yew is poisonous enough to kill
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ResearchGlow-in-the-dark proteins offer cheap and fast diagnostic tests
Covid-19 can be detected with the sensitivity of PCR and the ease of lateral flow
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BusinessPfizer to buy cancer biotech Seagen for $43 billion
Antibody-drug conjugate specialist will fill Pfizer’s cancer pipeline
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ResearchStudy challenges assumptions over how l-oligonucleotides behave in living systems
L-oligonucleotides are potentially cytotoxic but some could have unexpected therapeutic benefits
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ResearchPeptide tags that encode chemical libraries could revolutionise drug discovery
Simple strings of amino acids store over 4 gigabits of data, offering a highly stable solution for screening small molecule libraries