Medicinal chemistry – Page 5
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ResearchTherapeutic proteins can hitch a ride on parasite to bypass blood-brain barrier
Toxoplasma could be delivery agent for protein drugs – provided parasite can be made safe
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BusinessWeight-loss drugmakers bet billions on boosting supplies
Eli Lilly and Novo Nordisk invest to expand in-house manufacturing of GLP-1 drugs
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ResearchDrugs and vaccines could be freed from cold chains by hydrogel
Stiff gel prevents proteins from aggregating, preserving their therapeutic power
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ResearchNanopore proteins designed from scratch and turned into biosensors
Artificial ion channels used to detect disease indicators and pharmaceuticals
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ResearchCompanion compound for naloxone could boost opioid reversal effects, save lives
Discovery could help in fight against super-strength opioids such as fentanyl
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OpinionUnderstanding our brains is complicated, beware of simple ideas
Stepping up from chemistry to complexity
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FeatureBypassing the blood–brain barrier
Researchers are on a quest to outsmart and overcome the sophisticated security system of the brain. Julia Robinson reports on some of the approaches being studied
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FeatureWhy don’t we know how antidepressants work yet?
Selective serotonin reuptake inhibitors are at the centre of a collision between social and biochemical outlooks on depression, finds Andy Extance
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FeatureThe high price of a suntan
Skin cancer is on the rise in many countries around the world, but so are the methods to treat it. Bárbara Pinho reports
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BusinessModerna’s mRNA vaccine approved for RSV
US approval adds complementary option to protein-based vaccines for respiratory syncytial virus
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ResearchConjugate vaccine curbs xylazine effects in mice
Proof-of-concept for therapy that harnesses immune system to fight fentanyl adulterant
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OpinionWill science ever reach an end?
While the rate of discoveries in any field may slow over time, the frontier creeps ever further
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BusinessPan-cancer approval shows huge potential for antibody–drug conjugates
Enhertu gains approval based on gene expression rather than tumour location
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Research‘Late-stage saturation’ could improve drugs' effectiveness
Approach turns flat aromatic structures into three-dimensional saturated molecules with improved medicinal properties
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ResearchHow HIV drugs have changed over the decades
From one big pill that only prolonged lives a few months, through the 20 pills a day years to modern combination therapies, treating HIV is a science success story
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OpinionLab automation gives me more time at the top of the mountain
Getting back to the bench reminds Derek Lowe how much has changed in 40 years
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ResearchScreening reveals thousands of ‘undrugged, yet druggable’ proteins
Collaboration involving Pfizer develops freely accessible AI tool to probe protein–compound interactions
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ResearchNew mechanism identified that is potentially linked to very early stages of Alzheimer’s
Understanding role of fragments of amyloid protein could lead to novel therapies for the disease
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NewsExplainer: nitazenes and xylazine – a cause for concern
Why is the use of these highly potent synthetic drugs rising dramatically?
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ResearchCould mechanochemistry have saved Abbott Laboratories $250 million?
Ball milling solves problem of disappearing ritonavir polymorph