Medicinal chemistry
The latest chemistry news and research on medicinal chemistry including drug discovery, clinical trials, toxicology and science of disease, from the Royal Society of Chemistry's magazine, Chemistry World
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BusinessPfizer’s green chemistry team turns 25
What began as a grassroots initiative has become embedded across Pfizer’s research and manufacturing operations, helping reshape processes from Viagra to Paxlovid
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ResearchCovalent drugs just got a new ‘spring-loaded’ warhead
Sulfur(IV) reagent allows late-stage installation of bicyclobutanes to drug molecules, expanding a limited tool box
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BusinessOral cholesterol-lowering peptide approved after a decade in development
Merck & Co’s Lipfendra (enlicitide) employs 13 enzymes in biocatalytic synthesis
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ResearchRe-engineered psychedelic drug retains therapeutic activity in mice, while limiting negative side effects
Rationally designed molecular structure targets a specific subset of serotonin receptors, and potentially offers a route towards safer psychedelic treatments
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BusinessIndia’s generic GLP-1 drugs are (mostly) booming
Manufacturing problems for some manufacturers have led to production pauses and recalled batches of diabetes and weight loss drugs
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Podcast50 years after Seveso & changing the way we separate hydrocarbons
What have we learned 50 years on from the Seveso accident? And we discuss three promising membrane strategies that could replace fractional distillation in crude oil refineries.
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WebinarOne goal, three industries: retrosynthesis for pharma, agrochemicals and flavours & fragrances
Join us on 15 September as we explore the latest in AI-powered retrosynthetic software, evaluating its performance across three different industries
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BusinessRegulators push Amgen to withdraw drug due to data manipulation
Questions raised over safety and efficacy of Tavneos (avacopan)
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BusinessRewriting genetic medicine
Scribe Therapeutics will soon begin clinical trials for its epigenetic treatment to tackle ‘bad’ cholesterol
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ResearchMetabolised antibiotics can drive antimicrobial resistance just as much as their parent compounds
Studies on wastewater show that antibiotic transformation products may play an underappreciated role in driving antimicrobial resistance
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ResearchClever chemistry turns antibiotic-resistant bacteria’s own defences against them
Photosensitiser is activated by enzyme linked to resistance, making bacteria vulnerable to light therapy
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OpinionWhat kinds of reactions do you do most?
Variety may be the spice of life, but there’s space for the boring but effective
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OpinionGSK agrees $10 billion deal for Nuvalent cancer drugs
Deal includes two late-stage molecules to augment GSK’s renewed cancer therapy pipeline
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NewsCroatian researchers thrust into limelight as their 1990s’ peptide discovery goes mainstream in the US
Trump administration hopes to approve peptides popular with MAHA wellbeing advocates. How are the researchers at the centre of this coping with sudden media fame?
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NewsWhat kind of damage has RFK Jr’s health department inflicted on vaccine research in the US so far?
Since becoming health secretary in early 2025, Robert F Kennedy Jr has confirmed the worst fears of his critics
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ResearchRepurposed anticancer agent becomes sound-activated antibacterial drug candidate
Compound offer resistance-free treatment for deep-tissue infections
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BusinessEU looks to boost protective trade policy against Chinese imports
Critical Medicines Act and rumoured chemicals rules aim to decrease China’s supply chain dominance
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BusinessUS FDA commissioner Makary resigns amid chaos and questions
Marty Makary’s departure, amid reports that Trump planned to fire him, is the result of an ‘inherited crisis’ and ‘shifting FDA standards’, BIO says
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Business‘Basic research is needed more than anything else’
Christian Hackenberger, co-founder of Tubulis, is excited that his team’s initial research is now creating clinical impact
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PodcastVanadium-based medicines & sustainable labs
Vanadium-based medicines? We discuss the 23rd element’s little-known potential in pharmaceuticals. Plus, how labs across the UK are making achievable changes to increase their sustainability.