Medicinal chemistry
The latest chemistry news and research on medicinal chemistry including drug discovery, clinical trials, toxicology and science of disease, from the Royal Society of Chemistry's magazine, Chemistry World
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PodcastDrugging the ‘undruggable’ cancer proteins & conserving the Bayeux Tapestry
How did molecular glues help crack one of cancer’s toughest targets? And we explore the chemistry behind the investigation and conservation of the Bayeux Tapestry.
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Opinion‘Molecular glues’ are sticking it to cancer
Compounds that enhance selected protein–protein interactions to interfere with signalling or send proteins to be destroyed are making it possible to influence processes that were previously considered ‘undruggable’
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BusinessProtein degrading breast cancer drugs navigate bumpy road to market
Camizestrant is now approved in US, UK and Europe despite uncertainty over long-term benefit, while vepdegestrant is approved in the US
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BusinessUS approves pancreatic cancer treatment that targets ‘undruggable’ proteins
Daraxonrasib success offers hope of further approvals for Ras-inhibitor drug candidates targeting various cancers
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BusinessAntibody data manipulation extends to thousands of images across 15 suppliers
Sleuths discover widespread, systematic alteration of Western blots and other antibody data
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PodcastAdvances in CAR-T cancer therapy & carbon materials’ hidden defects
What does recent success with bladder tumours mean for solid cancer treatment? And we discuss why scientists are rethinking how they assign peaks in spectra of carbon-based materials.
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ResearchBenchmark flaws may be distorting AI drug-discovery leaderboards
Audit identifies subtle but consequential issues, such as conflicting labels and train–test leakage, in numerous benchmark datasets
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BusinessProtein degrader approval offers hope to relapsed multiple myeloma patients
Highly potent molecular glue drug iberdomide doubles the number of patients reaching fewer than one myeloma cell per 100,000 in bone marrow
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FeatureCracking the ubiquitin code to unlock new drug targets
The approval of the first Protac cancer drug marks a turning point in medicine – but scientists are only beginning to decode the complex molecular language that makes it possible
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OpinionChemistry contains multitudes
There’s room (and need) for all the various subspecies of chemical scientists
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ResearchOrganocatalyst streamlines oligonucleotide drug synthesis
New reaction controls phosphorus stereochemistry during the synthesis of phosphorothioate oligonucleotides
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OpinionArtificial intelligence or clever artifice?
It’s important to be realistic about what AI can, and can’t, achieve, across the chemistry enterprise
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BusinessPfizer’s green chemistry team turns 25
What began as a grassroots initiative has become embedded across Pfizer’s research and manufacturing operations, helping reshape processes from Viagra to Paxlovid
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ResearchCovalent drugs just got a new ‘spring-loaded’ warhead
Sulfur(IV) reagent allows late-stage installation of bicyclobutanes to drug molecules, expanding a limited tool box
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BusinessOral cholesterol-lowering peptide approved after a decade in development
Merck & Co’s Lipfendra (enlicitide) employs 13 enzymes in biocatalytic synthesis
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ResearchRe-engineered psychedelic drug retains therapeutic activity in mice, while limiting negative side effects
Rationally designed molecular structure targets a specific subset of serotonin receptors, and potentially offers a route towards safer psychedelic treatments
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BusinessIndia’s generic GLP-1 drugs are (mostly) booming
Manufacturing problems for some manufacturers have led to production pauses and recalled batches of diabetes and weight loss drugs
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Podcast50 years after Seveso & changing the way we separate hydrocarbons
What have we learned 50 years on from the Seveso accident? And we discuss three promising membrane strategies that could replace fractional distillation in crude oil refineries.
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WebinarOne goal, three industries: retrosynthesis for pharma, agrochemicals and flavours & fragrances
Explore the latest in expertly-coded retrosynthetic software, as we look at its performance across three different industries
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BusinessRegulators push Amgen to withdraw drug due to data manipulation
Questions raised over safety and efficacy of Tavneos (avacopan)