Medicinal chemistry
The latest chemistry news and research on medicinal chemistry including drug discovery, clinical trials, toxicology and science of disease, from the Royal Society of Chemistry's magazine, Chemistry World
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BusinessRewriting genetic medicine
Scribe Therapeutics will soon begin clinical trials for its epigenetic treatment to tackle ‘bad’ cholesterol
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ResearchMetabolised antibiotics can drive antimicrobial resistance just as much as their parent compounds
Studies on wastewater show that antibiotic transformation products may play an underappreciated role in driving antimicrobial resistance
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ResearchClever chemistry turns antibiotic-resistant bacteria’s own defences against them
Photosensitiser is activated by enzyme linked to resistance, making bacteria vulnerable to light therapy
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OpinionWhat kinds of reactions do you do most?
Variety may be the spice of life, but there’s space for the boring but effective
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OpinionGSK agrees $10 billion deal for Nuvalent cancer drugs
Deal includes two late-stage molecules to augment GSK’s renewed cancer therapy pipeline
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NewsCroatian researchers thrust into limelight as their 1990s’ peptide discovery goes mainstream in the US
Trump administration hopes to approve peptides popular with MAHA wellbeing advocates. How are the researchers at the centre of this coping with sudden media fame?
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NewsWhat kind of damage has RFK Jr’s health department inflicted on vaccine research in the US so far?
Since becoming health secretary in early 2025, Robert F Kennedy Jr has confirmed the worst fears of his critics
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ResearchRepurposed anticancer agent becomes sound-activated antibacterial drug candidate
Compound offer resistance-free treatment for deep-tissue infections
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BusinessEU looks to boost protective trade policy against Chinese imports
Critical Medicines Act and rumoured chemicals rules aim to decrease China’s supply chain dominance
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BusinessUS FDA commissioner Makary resigns amid chaos and questions
Marty Makary’s departure, amid reports that Trump planned to fire him, is the result of an ‘inherited crisis’ and ‘shifting FDA standards’, BIO says
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Business‘Basic research is needed more than anything else’
Christian Hackenberger, co-founder of Tubulis, is excited that his team’s initial research is now creating clinical impact
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PodcastVanadium-based medicines & sustainable labs
Vanadium-based medicines? We discuss the 23rd element’s little-known potential in pharmaceuticals. Plus, how labs across the UK are making achievable changes to increase their sustainability.
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OpinionThe evolving landscape of pain drug discovery
Harnessing the power of human-relevant in vitro models
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OpinionMajor drug regulators advancing routes to reduce animal testing
US, UK and EU all have goals to eliminate animal testing
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OpinionWhen vanadium almost changed how we treat type 2 diabetes
Chris Orvig tells the story of BEOV
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ResearchVanadium’s promise in medicine and the researchers who refuse to give up
It mimics phosphate, kills cancer cells in the lab and almost changed how we treat diabetes. So why has a vanadium compound never made it to the clinic?
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FeatureThe curious case of disappearing polymorphs
From crystallographers’ beards to billion-dollar lawsuits, the phenomenon of disappearing polymorphs has puzzled chemists for decades. Now researchers are finally unravelling the science behind why stable crystal forms suddenly vanish – and discovering how to bring them back
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ResearchInside-out peptides are part of a new class of isomerism
Could an overlooked conformational contortion invalidate existing drug patents?
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OpinionIndia’s generic semaglutide surge
As patents on Novo Nordisk’s diabetes and weight loss blockbusters expire, generic makers have their versions ready
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FeatureNew treatments offer hope for neglected snakebite victims
Nina Notman meets the scientists developing recombinant antivenoms and small molecule inhibitors to save the lives and limbs of snakebite patients, who number in the their hundreds of thousands