All Medicinal chemistry articles – Page 8
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BusinessDementia slips down pharma agenda
Pfizer, Shire, Acorda and Axovant rethink their neuroscience strategies
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Research
Natural and unnatural peptides team up to target Ebola
New method to hunt down protease-stabilised peptide inhibitors of large proteins
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Research
Suzuki–Miyaura–hydrogenation targets 3D drugs
Researchers design a new pathway to make sp3 enriched drug molecules
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Business
Pharmaceuticals roundup 2017
Political influence has strongly shaped industry activity in the past year
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Opinion
Changing the reproducibility rulebook
It pays to know when taking shortcuts is acceptable, and which it’s safe to take
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Feature
From venoms to medicine
Venoms are a treasure trove of peptides that may provide a bounty of novel painkillers
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Business
Targeting rare diseases
Is working on genetic mutations that affect only a few in every thousand people risky?
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Opinion
Natural selection
Bioactive compounds don’t just inspire new synthetic strategies, they’re also the ultimate test
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Opinion
Rise of the biologics
Antibodies, RNA and gene therapy don’t necessarily compete with small molecule drugs – and they all rely on chemistry
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Business
Drug formula change infuriates French thyroid patients
Poor communication of changes to Merck KGaA’s levothyroxine has led to complaints of side effects
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Business
US to invest $160m in cancer partnership
Funds will be backed up with $55m from 11 companies to advance new cancer treatments that harness the immune system
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Podcast
Cinnarizine (stugeron)
Neil Withers relives a choppy (and messy) sea voyage to bring us the science of anti-seasickness drug cinnarizine
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Careers
Video games are enabling discovery
Gamification is harnessing an untapped army of citizen scientists
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Feature
The long road to an HIV vaccine
A vaccine may not be available anytime soon, but its proponents are hard at work
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Research
Super-electrophilic ions enable selective modification of bioactive molecules
New technique will help medicinal chemists explore chemical space
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Opinion
An opportunity ignored
Dismissing ideas that were ‘not invented here’ is like walking past a $100 bill
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Business
Takeda tightens focus on core areas with multiple deals
Japanese firm is remodelling its R&D efforts through collaboration and licensing deals, and selling off non-core businesses
