Medicinal chemistry – Page 8
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OpinionThe toxic nature of yew, the tree of the dead
Historically associated with resurrection, yew is poisonous enough to kill
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ResearchGlow-in-the-dark proteins offer cheap and fast diagnostic tests
Covid-19 can be detected with the sensitivity of PCR and the ease of lateral flow
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BusinessPfizer to buy cancer biotech Seagen for $43 billion
Antibody-drug conjugate specialist will fill Pfizer’s cancer pipeline
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ResearchStudy challenges assumptions over how l-oligonucleotides behave in living systems
L-oligonucleotides are potentially cytotoxic but some could have unexpected therapeutic benefits
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ResearchPeptide tags that encode chemical libraries could revolutionise drug discovery
Simple strings of amino acids store over 4 gigabits of data, offering a highly stable solution for screening small molecule libraries
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ResearchSweetener erythritol linked to heart problems
Comprehensive study discovers high dietary intake of erythritol correlates with increased risk of heart attack similar to having diabetes
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ResearchDataset with millions of entries set to help AI find new drugs
Neural networks perform better when trained on larger datasets
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ResearchThe hunt is on for vaccine ingredients that don’t come from wild sharks
Yeast can provide the raw materials and chemical wizardry can transform them
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ResearchLipophilicity helps explain psychedelic drugs’ therapeutic effects
Understanding why psychedelic drugs that bind to serotonin receptors promote neuron growth, while serotonin itself does not
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BusinessContaminated cough syrups death toll passes 300 in four months
Deadly glycol contamination discovered in Uzbekistan, following cases in The Gambia and Indonesia
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ResearchAnalysing blood chemistry from a single drop
Mass spectrometry determine the levels of thousands of chemicals in a ‘microsample’ of human blood
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ResearchAlphaFold works with other AI tools to go from target to hit molecule in 30 days
End-to-end AI drug discovery process predicts potential inhibitors for a protein implicated in liver cancer
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BusinessEncoding creativity in drug discovery
Machine learning can complement and reinforce human intuition and experience
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OpinionA decade on Crispr is already poised to deliver on its promise
Gene editing could transform healthcare but no disease should be forgotten
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![Chemical structure of Pillar[6]MaxQ](https://d2cbg94ubxgsnp.cloudfront.net/Pictures/100x67/6/2/1/523621_chempr1747_proof1_891632.jpg)
ResearchMolecular trap that snares many different drugs could save lives during overdoses
Macrocyclic compound can mop up drugs of abuse in animal tests – including those for which no reversal agent exists
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OpinionSetting drug development speed records
The pandemic treatment sprint was spectacular, but hard to match under less unusual circumstances
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ResearchBenchtop machine automates synthesis of drug screening hits
System could boost the efficiencies of drug discovery campaigns
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BusinessUK antibiotics supply chain stretched by surge in Strep A infections
Government enacts protocols to enable substitute treatments and recommends preventive prescriptions in severe cases
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NewsCrispr moves into the clinic
A mere decade after its discovery Crispr is already in clinical trials for everything from sickle cell disease to HIV and cancer