All Medicinal chemistry articles – Page 8
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NewsAsthmatics encouraged to switch to lower carbon footprint inhalers
The majority of inhalers prescribed in UK contain a potent greenhouse gas
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Research
Droplet screening set to accelerate immunotherapies into the clinic
Single-cell technique eliminates inefficiencies when identifying immune cells active against specific cancers
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Research
Co-crystals fish out cannabinoid from plant extract
Purifying cannabidiol from natural cannabis extract made cheap and easy thanks to amino acid partner
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Business
Nurturing the next biotech generation
As incubator environments evolve, options for new companies looking for support are broadening
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Research
New family of peptides from extremophile show antibiotic promise
Scientists isolate salinipeptins from a bacterium living in America’s Dead Sea
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Sponsored
Small particles making a big splash in clinical development
Nanoform is investigating how to tackle clinical attrition rates through nanonisation of APIs
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Sponsored
Investigating multi-dimensional problems in drug substance development
Finding solutions to the biggest challenges faced during drug substance development relies on properly integrating analytical and production expertise
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Podcast
Vinblastine and vincristine: Vinca alkaloids
Kat Arney unearths a story of an overlooked female researcher in the search for the origins of cancer drugs found in plants
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Research
Small molecule finds flu virus’s weak spot
Drug candidate that targets highly conserved region of virus gave mice complete protection from swine flu
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Feature
The battle to lose weight
Losing weight – and not putting it back on – is about much more than willpower. Nina Notman reports on the drugs trying to penetrate the complex metabolic web of hunger and satiety.
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Research
Cracking enzyme structure offers new way to treat rare heart diseases
Solution was found by combining protein with its chaperone
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Research
Genetically engineered yeast brews up heady mix of natural and unnatural cannabinoids
Biotech yeast makes low-cost, high-quality THC and CBD – and cannabinoids never seen before – without growing cannabis plants
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Research
The five reactions on every organic chemist’s wish list
Synthesis has some catching-up to do to create the reactions every drug discovery chemist dreams of
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News
Personalised medicine has failed to live up to the hype, researchers claim
Predictions that Human Genome Project would usher in an era of tailored therapies have largely failed to come true
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Opinion
How teenagers are disrupting drug discovery
A citizen science project to improve access to malaria drugs
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Research
Alzheimer’s linked to infection of the brain by gum disease bacterium
Drug firm is developing treatment to inhibit bacterial enzymes believed to be damaging important protein
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Research
Screening strategy pursues photocatalytic couplings for drug discovery
High-throughput screening and flow-based scale-up combo identifies chemistry needed to functionalise drug fragments and obtain useful amounts of product
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Research
Patent-busting AI tool navigates around protected drug pathways
Organic retrosynthesis software can identify key bonds involved in patented reactions to find alternative pathways
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Opinion
What are the rate-limiting steps in drug discovery?
Getting more drugs to market is not just a chemistry problem
