All Medicinal chemistry articles – Page 10
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NewsGetting a better grasp of manganese to fight flu
A drug that can hold onto two metals atoms rather than just one becomes 1000 times more potent at knocking out a flu virus enzyme
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Research
Bacteria churn out a million potential protein drugs
Modified bacteria produce enormous library of macrocycles, one of which inhibits a HIV protein
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Feature
The chemistry of the microbiome
Our gut bacteria are carrying out chemistry on our behalf, but without us knowing much about it. Now, scientists are starting to examine their enzymes
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Feature
The antibiotic countdown
Where are the next generation of antibiotics going to come from? Clare Sansom looks at the pipeline
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Research
Antimalarial plant's chlorophyll catalyses drug synthesis
New ‘green’ method makes malaria-fighting artemisinin’s synthesis faster and cheaper with industrial production planned for 2021
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Business
BMS stimulates cancer drug hopes with giant collaboration
Immunooncology pioneer will pay up to $3.6bn in hope Nektar drug will help non-responders
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Business
Celgene takes a punt on M&A
Cancer specialist bags Juno therapeutics and Impact Biomedicines
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Business
FDA new drug approvals more than doubled in 2017
The FDA approved 46 new drugs last year – the highest number in over two decades – due to factors like streamlined policies at the agency
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News
Changing political climate threatens US cannabis research
Trump administration reverses rule protecting states with legalised marijuana
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Business
Dementia slips down pharma agenda
Pfizer, Shire, Acorda and Axovant rethink their neuroscience strategies
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Research
Natural and unnatural peptides team up to target Ebola
New method to hunt down protease-stabilised peptide inhibitors of large proteins
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Research
Suzuki–Miyaura–hydrogenation targets 3D drugs
Researchers design a new pathway to make sp3 enriched drug molecules
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Business
Pharmaceuticals roundup 2017
Political influence has strongly shaped industry activity in the past year
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Opinion
Changing the reproducibility rulebook
It pays to know when taking shortcuts is acceptable, and which it’s safe to take
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Feature
From venoms to medicine
Venoms are a treasure trove of peptides that may provide a bounty of novel painkillers
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Business
Targeting rare diseases
Is working on genetic mutations that affect only a few in every thousand people risky?
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Opinion
Natural selection
Bioactive compounds don’t just inspire new synthetic strategies, they’re also the ultimate test
