Medicinal chemistry – Page 7
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OpinionExploring new fragments of chemical space
How medicinal and process chemists are working together to build better drugs
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BusinessIllumina to give up Grail as competition appeals fail
Sequencing giant will sell off its former spin-out in accordance with regulator orders
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BusinessPharmaceuticals roundup 2023
Regulatory and pricing reforms have topped industry agendas in 2023, while weight loss drugs surged and Covid-19 therapies waned
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FeatureCubanes help drugs take the strain
Medicinal chemists are increasingly exploring strained ring systems, George Barsted reports, believing they can serve as replacements for conventional building blocks in pharmaceuticals
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ResearchBiocatalysis breakthrough enables synthesis of lactam building blocks for drugs
Enzymatic cyclisation of oxazolone reagents offers a cheap and simple route to important antibiotic precursor
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ResearchNanopore test could identify misfolded proteins in Alzheimer’s and Parkinson’s disease
Sensor could provide more accurate diagnoses and help doctors track progress of neurodegenerative diseases
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ResearchAntibiotic adjuvant designed to subvert bacterial defence mechanisms
Amphiphilic molecule helps obsolete antibiotics accumulate and act within bacteria
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OpinionCompounding problems
Regulating the line between a vital service and grey-market profiteering is a mess
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ResearchNew insights into polyamorphism could influence how drugs are formulated
Findings suggest dihedral angle distribution might explain why polyamorphs have different physical properties
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BusinessUK becomes first country in the world to authorise a Crispr-based gene therapy
Treatment aims to cure patients with β-thalassaemia and sickle-cell disease
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NewsFisheries agency concludes it’s ‘very unlikely’ pyridine behind UK crustacean deaths after new tests
Cause of mass die-offs in late 2021 and early 2022 still a mystery
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BusinessWeight-loss drug shortages prompt copycats and counterfeits
Novo Nordisk and Eli Lilly have struggled to meet huge demand for new hormone mimic obesity treatments
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ResearchInsulin medicines more resilient to temperature than previously thought
Review suggests more lenient storage guidelines could make diabetes treatments more accessible
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ResearchUnderwater device reveals marine chemical diversity
I-Smel device probes metabolites produced by Mediterranean sponges
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BusinessThree US juries side with cancer victims over Bayer on Roundup
Bayer unit Monsanto has lost its ‘winning streak’ of nine defence verdicts, and the company plans to appeal
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ResearchControlling insulin activity in cells with ‘DNA origami’
Insulin–DNA nanorods elicit geometry-dependent insulin activity, which could lead to more targeted treatments for diabetes
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FeatureBattling long Covid with drugs
The challenge of finding drugs for a poorly understood disease with many symptoms is clear. Clare Sansom looks at the work going on to help the people suffering in its shadow
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ResearchGenetic-editing of chickens protects them from catching the flu
Approach heralds new way to make animals resistant to disease
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OpinionMoving beyond protein structure
Efforts to understand how intrinsically disordered regions interact have produced a variety of answers
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OpinionLetters: October 2023
Readers discuss antibiotic challenges, muse about micrographs and remember Philip Eaton