Medicinal chemistry – Page 7
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BusinessMerck & Co to cut 6000 jobs, Moderna to cut around 500
Both firms aiming to make significant reductions in annual costs by reorganising
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ResearchAI tools turned to creating designer proteins for personalised cancer therapies and antibiotics
Powerful new class of AI model could dramatically speed up process of producing new kinds of drug candidates
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NewsAs AI-designed drug looks to pass final hurdle, will this tech change drug discovery forever?
AI-led drug for chronic lung disease set to enter phase 3 clinical trials, though experts remain divided on AI’s impact in pharma
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OpinionLearning about chemistry in prenatal class
Opportunities for infographics to contribute to health literacy
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OpinionChina’s drug development charge
Reforms and state support have fuelled domestic and foreign investment in pharmaceutical
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ResearchMorphine analogues kill pain with fewer negative side effects
Redesign of the potent painkiller’s core prevents breathing suppression and reduces addiction-related behaviours in mice
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WebinarWomen’s health: insights in research and inclusion
Learn about the history and importance of the gender gap currently impacting women’s health sciences
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NewsWhy is a prehistoric creature still vital for the pharmaceutical industry?
Every year, horseshoe crabs are harvested for their blue blood, but alternatives are now coming through that could help protect these ancient animals
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ResearchDNA barcodes can make drug discovery screens miss potential medicines
Flawed data is likely compromising machine learning methods
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BusinessUS approves twice yearly injection to prevent HIV
Yeztugo (lenacapavir) provided near-total protection against infection in clinical trials
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FeatureHibernation awakens interest for drug discovery
With many different species entering torpor for a variety of reasons, scientists are looking to their sleepy secrets for ways to treat human diseases. Anthony King reports
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BusinessSanofi to buy Blueprint Medicines for over $9 billion
Blueprint has one approved drug and enhances Sanofi’s immunology portfolio
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OpinionNon-hallucinogenic psychedelics
Chemical insights and advances are contributing to a new therapeutic avenue for mental health conditions
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ResearchAFM maps the way collagen unfolds and refolds in the body
New insights could aid understanding of connective tissue disorders
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ResearchSelective C–H bond fluorination enables conformational reporting in a complex natural product
Radical fluorination leaves extant functional groups intact
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ResearchNanocomplex becomes a master of shape-shifting to target tumour cells
Switching from nanofibres in the blood to virus-like particles in a tumour environment brings drugs to where they are needed
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OpinionIgnoring women’s health shouldn’t be an option
Developing therapies for conditions that predominantly affect women is a neglected, but enormous, opportunity
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WebinarModelling amorphous solid dispersion (ASD) release mechanisms
Learn how thermodynamic modelling and molecular simulation can help our understanding of amorphous solid dispersion
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FeatureFixing medicine’s gender gap
For centuries, the default subject in medicine research and training has been the male. Julia Robinson talks to the scientists and clinicians trying to improve things for the other 51% of humanity
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OpinionWomen are not just another confounding factor in drug development
Ignoring physiological differences between the sexes is indefensible