Organic chemistry – Page 4
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ResearchForgotten borole synthesis expands family of antiaromatic compounds
Study investigates how benzene-fused borole compares to its non-fused and doubly-fused cousins
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ResearchElectrochemical reaction outcomes controlled by customised AC waveforms
Programmed alternating currents allow researchers to choose between reaction mechanisms with the flick of a switch
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ResearchSuper-fast automated synthesis promises to make chemistry accessible to many more
Order of magnitude improvement in speed result of technology optimisation
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ResearchHarnessing carbene reactivity with light
Two-step photocatalytic strategy produces metal carbenes easily and safely
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ResearchPhotochemistry sheds light on the direct functionalisation of native sugars
New radical reaction reduces the number of protection and deprotection steps needed, accelerating discovery of sugar compounds
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ResearchPillar[5]arene gets fully furnished with bulky aromatics
Synthesis developed by pillararene pioneers overcomes steric hindrance while preserving macrocycle’s pillar-shaped structure
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ResearchFrom pollutant to painkiller: hazardous halogenated wastes become a safe chlorine source
Persistent pollutants can be used to produce painkillers
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ResearchIntermediate considered ‘too reactive to isolate’ finally tamed
Nitrene species stabilised for three days with careful choice of substituent
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FeatureSparking industry’s interest in electrosynthesis
Using electrons instead of reagents offers many potential benefits, but there are still barriers to overcome, as Rachel Brazil reports
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ResearchClever activation strategy widens access to phosphazene superbases
Superbases stored as stable carboxylate salts – adding epoxide releases their full chemical potential
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ResearchStudy questions sustainability benefits of replacing palladium with nickel in cross-coupling reactions
Common belief that Earth-abundant metals are green replacements for palladium may be misleading
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OpinionWill science ever reach an end?
While the rate of discoveries in any field may slow over time, the frontier creeps ever further
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ResearchSimple preparation method improves access to long-known superacid
Aluminium tris(fluorosulfate) synthesised in a single step
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ResearchSimplified hydroformylation replaces rhodium with base metal
Bench-friendly asymmetric hydroformylation swaps toxic gas and expensive catalyst for cheap reagents and mild conditions
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NewsWhat the dichloromethane ban might mean for university labs in the US
The lab use requirements outlined in the agency’s workplace chemical protection plan are impractical for academic institutions, the ACS says
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ResearchHow A-level chemistry solved the 200-year-old problem with the haloform reaction
Mechanistic analysis reveals unknown steps in undergraduate staple, the haloform reaction
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BusinessPan-cancer approval shows huge potential for antibody–drug conjugates
Enhertu gains approval based on gene expression rather than tumour location
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ResearchPorous organic ‘cage of cages’ crystalline structure predicted by computational modelling
Organic cages have been used as precursors to synthesise higher order porous structures, adding to their functionality while the ability to solution process them is retained.