Organic chemistry – Page 2
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Opinion(−)-Novofumigatonin
Oxidations abound in this satisfying synthesis, with a delicate nitrile hydrolysis to finish
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ResearchQuantum tunnelling drives aromaticity flip-flop
Augmented pentalene structure could be a molecular Schrödinger’s cat, aromatic and antiaromatic at the same time
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ResearchThis fragment-based drug discovery library is designed to be sociable
Study targets a key bottleneck in hit to lead optimisation by designing fragments that are both structurally diverse and easy to elaborate
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ResearchAll stirred up: chemical engineers refute claims that ‘stirring doesn’t matter’
Failing to mix reactions in heterogeneous or industrial systems could cause numerous issues and might even be dangerous, preprint claims
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ResearchDihydropyrazine-embedded macrocycles behave like supersized cycloalkanes
Giant molecular rings that mimic the puckered shapes of cyclobutane, cyclopentane and cyclohexane could offer new insights into conformational dynamics
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Research‘Stimulating discovery’ leads to strategy to swap oxygen in saturated rings
Skeletal editing pushed beyond aromatic structures, sparking new opportunities in drug discovery
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WebinarSYNTHIA for chemists: faster route design
Discover how SYNTHIA accelerates retrosynthesis by helping chemists design, compare and refine routes with customisable filters and commercial building blocks
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OpinionMy arcane and curious connection to metal-organic frameworks
Fernando Gomollón-Bel uncovers a link between his hometown and the 2025 Nobel prize in chemistry
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NewsMeet the three scientists who have just won the Nobel prize in chemistry
Learn about the lives of newly minted chemistry Nobel laureates Susumu Kitagawa, Richard Robson and Omar Yaghi
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NewsExplainer: why have metal–organic frameworks won the Nobel prize in chemistry?
Susumu Kitagawa, Richard Robson and Omar Yaghi scooped the Nobel prize for their work on MOFs – here’s everything you need to know
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News2025 chemistry Nobel prize goes to the scientists behind metal–organic frameworks
Susumu Kitagawa, Richard Robson and Omar Yaghi take top prize for discovery and development of versatile materials with a huge surface area
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NewsThe 2025 Nobel prize in chemistry as it happens – live
Join us as we provide analysis and commentary in the run up to the announcement of the biggest prize in chemistry
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Webinar200 years of benzene, the peculiar molecule that defied classification
Join us to celebrate benzene’s 200th birthday
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OpinionBuilding better batteries with chemistry’s toolbox
How organic chemistry powers the development of sustainable batteries
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ResearchOne-pot atom swap chemistry allows direct indole-to-benzimidazole conversion
Industrial chemists set to benefit from addition to skeletal editing toolbox
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ResearchComprehensive investigation suggests stirrer bars have little impact on reactions
Examination of over 300 organic reactions suggests stirring is nothing more than a placebo
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ResearchPorphyrin ring pushes the size limit for fully aromatic molecules
Nanoring structure features 18 porphyrin units linked together by butadiyne units
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ResearchReviving organobismuth chemistry
Despite its low cost and low toxicity, bismuth has found limited applications in organic synthesis. Liam Ball is working to change that
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WebinarExploring the frontiers of the periodic table: bismuth catalysis and its applications
Learn about state-of-the-art synthesis coming from one of the world’s leading catalysis research groups
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ResearchStereochemical editing used to tune explosive power of cage-like energetic materials
Stereoisomers found to exhibit substantial differences in density, stability and detonation performance