All Organic chemistry articles – Page 2
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ResearchStreamlined synthesis of quinine showcases sustainable organic strategy
Five pot synthesis delivers highest yield of antimalarial to date
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Research
Photochemistry frees arene functionalisation from metals
Sulfonium salts offer new possibilities for the alkylation and cyanation of aromatic molecules
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Research
Mechanochemistry set to expand availability of organomanganese reagents
Ball milling method avoids problems surrounding solution-based chemistry when synthesising arylmanganese nucleophiles
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Research
Benchtop machine automates synthesis of drug screening hits
System could boost the efficiencies of drug discovery campaigns
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Research
Manganese complex behind method for preparing silanols that uses water as an oxidant
By using water as an oxidising agent, the reaction eliminates additional reagents and unwanted side-products
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Feature
Fashion to dye for
Can colouring clothing be environmentally sustainable? Victoria Atkinson looks at how dyes have come full circle from their natural origins
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Research
Coca plants’ production pathway for cocaine finally unravelled
167-year-old biosynthetic mystery may be solved
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Opinion
Embracing oddities
When new chemistry looks like alchemy or witchcraft, it’s worth taking notice
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Research
Mystery surrounding metalation reaction’s reagent excess solved
Multiple ‘base-eating’ aggregates discovered in classic directed ortho lithiation
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Research
Quantum chemical analysis uncovers previously overlooked contributor to carbocation stability trend
Introducing substituents destabilises the parent substrates
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Research
Gigantic database of building blocks will help artificial intelligence uncover new organocatalysts
Publicly available dataset containing thousands of structures could help chemists develop data-driven reaction optimisation methods for organic synthesis
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Research
Fully automated synthesis robot sets new record in stereospecific carbon–carbon bond formation
The robotic platform can make six carbon–carbon bonds without human guidance
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Research
Chirality-flipping reaction could completely change total synthesis strategies
Photocatalytic reaction that inverts configuration of chiral carbon centres offers new stereochemical editing logic
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Research
Controversy surrounds corrected chemical structures
Researchers used machine learning-powered NMR prediction to correct improbable structures – but some of their revisions have been challenged
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Research
AI discovers the best general conditions yet for cross couplings, doubling yields
Algorithm works with robotic experimenter on tricky Suzuki–Miyaura reactions
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Feature
When will molecular electronics make the connection?
Computer chips based on single molecules may remain a work in progress, finds James Mitchell Crow but the technologies developed along the way are being used by chemists to explore their reactions
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Feature
How click conquered chemistry
Katrina Krämer tells the story of how click and bioorthogonal chemistry came to win the 2022 Nobel prize
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Research
Amide library created at speed with machine learning and stopped-flow chemistry
Approach used 90% less starting material than continuous flow equivalent
