Organic chemistry
The latest chemistry news and research on organic chemistry, including synthesis, natural products and total synthesis, reaction mechanisms and supramolecular chemistry, from the Royal Society of Chemistry's magazine, Chemistry World
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BusinessBoron plays a key role in new sleeping sickness drug
Acoziborole is the first single-dose treatment for both early and late stage sleeping sickness
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ResearchBreaking bonds and bringing disciplines together to replace one of chemistry’s most controversial molecules
Rebecca Trager meets an organic chemist catalysing the search for BPA replacements by connecting synthetic chemists, data scientists, toxicologists and polymer chemists
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OpinionTraffic jams in the chemical plant
What happens between a big order coming in and going out?
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ResearchElusive ‘dark matter’ diazo compounds captured from a human lung pathogen
Discovery might lead to simpler, safer ways to make diazo-based reagents
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FeatureFrustrated Lewis pairs mark 20 years of metal-free catalysis
James Mitchell Crow explains how an unexpected discovery in main group chemistry inspired two decades of chemical creativity, from carbon dioxide reduction to fluorocarbon recycling, offering sustainable alternatives to precious metal catalysis
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WhitepaperNovel non-pyrophoric organolithiums for synthesis
New, improved formulations of frequently used organolithium reagents that improve on safety, prevent pyrophoric reactions and improve shelf life
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ResearchPhotocatalytic skeletal editing technique migrates substituents to challenging meta-position
Meta-substituted aromatic rings are key structures in many drug molecules
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FeatureCone snail venom peptides offer new hope for pain relief
Cone snails deploy sophisticated venom cocktails to paralyse prey. Anthony King talks to the researchers harnessing these peptides to develop new pain medications
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ResearchNew computer file could standardise how chemists report MOF syntheses
File stores synthesis and characterisation data, much like files for crystal structures
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ResearchRadical chemistry pioneer Moses Gomberg probably made a trivalent carbon years before he realised
Recreation of Gomberg’s experiments suggests that he may have made a hypovalent carbon species years before reporting their discovery
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ResearchUnruly [1,2]-Wittig reaction tamed to produce products with precise stereochemistry
Stubborn rule-breaker becomes a model reaction by sidestepping radical reaction mechanism altogether
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FeatureUnravelling the chemistry behind the sea’s bioluminescent sparkle
Researchers are piecing together the unusual chemical reactions that enable dinoflagellates to create spectacular light displays in tropical bays. But the mechanism behind their bioluminescence remains one of nature’s most puzzling chemical mysteries
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WebinarHigh‑throughput retrosynthesis for real‑world chemistry
Discover how retrosynthesis software, paired with application programming interfaces, can accelerate route design, virtual screening and practical synthesis decisions
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Opinion(+)-Melicolone K
Sequential C–H activations open up the opportunity for an unusual transformation
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OpinionHow bird photography made me a better chemist
Payal Joshi draws inspiration for organic mechanisms from graceful avian poses
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Research‘Almost impossible to destroy’: material captures CO2 and frees it at the flick of a photoswitch
New class of porous materials can trap gases and release them on command
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ResearchEmbodying polymer chemistry with a purpose by upcycling plastics and trapping PFAS
For Frank Leibfarth, focussing on reactivity and selectivity helps him bridge the gap between fundamental and applied research
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ResearchMapping tool delivers quantitative visualisations of steric interactions
Technique uncovers subtle interactions that previous methods have missed
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ResearchAmino acids weave organic molecules into chiral knots
Rare chiral Solomon links formed in single step
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OpinionIs it cold in here?
Labs in Delhi, Aberdeen and Arizona will have different ideas of ‘room temperature’