Organic chemistry – Page 6
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FeatureHow to automate your lab
Whether it’s robots, automation or software hacks, Nessa Carson finds ways for everyone to improve how they work in the lab
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OpinionThe psychology of our future with AI
It’s time to accept that digitalisation is changing laboratory work, and embrace the opportunity
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ResearchFour new bonds to one carbon atom, in a single step
Accidental discovery shows that N-heterocyclic carbenes can act as sources of atomic carbon
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ResearchAI model accurately classifies reaction mechanisms
Machine learning ‘surpasses chemist experts’ in identifying chemical processes
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ResearchChemical chainmail constructed from interlocked coordination polymers
Simple synthesis yields an ‘infinite’ structure with applications in flexible materials
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ResearchStreamlined synthesis of quinine showcases sustainable organic strategy
Five pot synthesis delivers highest yield of antimalarial to date
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ResearchPhotochemistry frees arene functionalisation from metals
Sulfonium salts offer new possibilities for the alkylation and cyanation of aromatic molecules
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ResearchMolecular motor running on electricity mimics biological motors
The nanomachine is based on a [3]catenane and isn’t operated through a microscope tip, unlike others
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ResearchMechanochemistry set to expand availability of organomanganese reagents
Ball milling method avoids problems surrounding solution-based chemistry when synthesising arylmanganese nucleophiles
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ResearchBenchtop machine automates synthesis of drug screening hits
System could boost the efficiencies of drug discovery campaigns
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ResearchManganese complex behind method for preparing silanols that uses water as an oxidant
By using water as an oxidising agent, the reaction eliminates additional reagents and unwanted side-products
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FeatureFashion to dye for
Can colouring clothing be environmentally sustainable? Victoria Atkinson looks at how dyes have come full circle from their natural origins
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ResearchCoca plants’ production pathway for cocaine finally unravelled
167-year-old biosynthetic mystery may be solved
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ResearchRadium chelator researchers working to improve targeted cancer therapies
Oak Ridge National Lab team investigate factors underpinnning Ra2+ complex stability and selectivity in attempt to expand the therapeutic utility of radium-223
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OpinionEmbracing oddities
When new chemistry looks like alchemy or witchcraft, it’s worth taking notice
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ResearchMystery surrounding metalation reaction’s reagent excess solved
Multiple ‘base-eating’ aggregates discovered in classic directed ortho lithiation
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ResearchQuantum chemical analysis uncovers previously overlooked contributor to carbocation stability trend
Introducing substituents destabilises the parent substrates
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ResearchGigantic database of building blocks will help artificial intelligence uncover new organocatalysts
Publicly available dataset containing thousands of structures could help chemists develop data-driven reaction optimisation methods for organic synthesis
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ResearchAI beats human experts when it comes to peptide design
Algorithm throws up some counter-intuitive structures in contest