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OpinionCracking codons
Understanding how chemistry links RNA triplets to the properties of amino acids
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Opinion
Contribute to defeating malaria
The Medicines for Malaria Venture needs new compounds for screening and more chemists to join its open-souce drug discovery project
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Research
Fox urine compound as good as catnip for some felines
Dihydroactinidiolide is the first example of a compound excreted by a mammal that can elicit a catnip response
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Webinar
Finding new medicines for malaria
Join Chemistry World for this interactive webinar and explore some of the collaborative avenues of research looking for new medicines to prevent and treat one of our oldest foes.
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Research
Redox flow batteries charge up with peptide-based electrolytes
Study shows how electrolytes could be degraded using acid and heat
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Research
Rotting fish experiments reveal how organs fossilise
Most fossils are bones, but individual organs’ biochemistry determines whether they are preserved in rock
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Opinion
Why AlphaFold won’t revolutionise drug discovery
Protein structure prediction is a hard problem, but even harder ones remain
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Research
Teixobactin’s two pronged antibiotic attack mechanism revealed
Understanding of formation of deadly supramolecular structures could help build improved antimicrobials
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News
AlphaFold has predicted the structures of almost every known protein
Google offshoot DeepMind has released more than 200 million predicted 3D structures, covering nearly the entire protein universe
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Research
Theories on origin of enzymes’ catalytic power united
Transition state stabilisation and ground state destabilisation both reduce the energy barrier by enhancing charge density but vary in their timing
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Research
Mystery of how plants make strychnine solved 75 years after characterisation
Three-quarters of a century after Robinson and Woodward cracked structure chemists unravel poison’s biosynthesis
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Research
The odour of amity: how you smell can predict friendships
Strangers who smell alike tend to form an instant connection with each other on first meeting
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Research
Fossil molecules reveal dinosaurs’ bird-like metabolism
Thioethers preserved in bones show that most dinosaurs were warm-blooded, though T rex may have been particularly sluggish
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Opinion
An idea that clicked
Bioorthogonal reactions – doing chemistry inside living cells without blasting everything in sight – are no mean feat
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Opinion
Carolyn Bertozzi: ‘Shooting hoops is very meditative’
The celebrated chemical biologist who dreamed of being a rock star before inventing the field of bioorthogonal chemistry
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Feature
The bioorthogonal revolution
A set of reactions operating silently inside live cells or whole animals are lighting up chemical biology and inspiring new medicines, James Mitchell Crow finds
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Feature
Life’s chemistry goes through the looking glass
Chemists were taught that natural systems only use L-amino acids. Andy Extance finds out just how wrong that is proving
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News
Chemistry Nobel laureate Sidney Altman dies at 82
Canadian–American molecular biologist won the 1989 prize for discovering RNA’s catalytic ability
