Drug discovery and development – Page 3
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FeatureThe high price of a suntan
Skin cancer is on the rise in many countries around the world, but so are the methods to treat it. Bárbara Pinho reports
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BusinessModerna’s mRNA vaccine approved for RSV
US approval adds complementary option to protein-based vaccines for respiratory syncytial virus
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ResearchConjugate vaccine curbs xylazine effects in mice
Proof-of-concept for therapy that harnesses immune system to fight fentanyl adulterant
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OpinionWill science ever reach an end?
While the rate of discoveries in any field may slow over time, the frontier creeps ever further
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BusinessPan-cancer approval shows huge potential for antibody–drug conjugates
Enhertu gains approval based on gene expression rather than tumour location
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Research‘Late-stage saturation’ could improve drugs' effectiveness
Approach turns flat aromatic structures into three-dimensional saturated molecules with improved medicinal properties
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ResearchHow HIV drugs have changed over the decades
From one big pill that only prolonged lives a few months, through the 20 pills a day years to modern combination therapies, treating HIV is a science success story
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OpinionLab automation gives me more time at the top of the mountain
Getting back to the bench reminds Derek Lowe how much has changed in 40 years
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ResearchScreening reveals thousands of ‘undrugged, yet druggable’ proteins
Collaboration involving Pfizer develops freely accessible AI tool to probe protein–compound interactions
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NewsExplainer: nitazenes and xylazine – a cause for concern
Why is the use of these highly potent synthetic drugs rising dramatically?
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ResearchCross-coupling technique cracks open alcohols for chemical synthesis
A new alcohol–alcohol cross coupling reaction could become a powerful new tool for synthetic chemists
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ResearchNon-antibiotics with antibacterial activity could help in the fight against antimicrobial resistance
New analysis shows that non-antibiotic drugs kill bacteria through mechanisms that differ from those of conventional antibiotics
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OpinionHarnessing biodiversity through natural products research in the Philippines
Collaborative projects aim to produce cheaper and more effective medicines
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ResearchClassic cross-coupling reactions rerouted to make new products
Combination of Suzuki–Miyaura and Buchwald–Hartwig couplings produces carbon–nitrogen–carbon linked compounds
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OpinionFrom one sinking ship to another?
Biogen abandoning Alzheimer’s antibody aducanumab is unusual, but hardly surprising, says Derek Lowe
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BusinessBig deals confirm renewed interest in radiopharmaceuticals
Acquisitions of RayzeBio and Point Biopharma highlight the potential of targeting radioactivity directly to tumour cells
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ResearchPre-organising antibiotic structure could aid fight against resistance
Strategy that produced new antibiotic could allow researchers to repurpose existing antibiotics
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FeatureMore than a mirror-image: left-handed nucleic acids
Now a biological reality, researchers are starting to figure out the many roles of left-handed nucleic acids such as Z-DNA – from immunity to controlling our genetics. Rachel Brazil reports
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ResearchUnravelling enzyme pathway of Taxol precursor brings synthetic production of cancer medicine closer
Expression of nine genes in tobacco plants led to formation of complex precursor of drug
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ResearchD-trypsin synthesis enables sequencing of mirror-image proteins
Reversing the chirality of a protein-digesting enzyme could aid the development of mirror-image therapeutics