Drug discovery and development – Page 3
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FeatureMore than a mirror-image: left-handed nucleic acids
Now a biological reality, researchers are starting to figure out the many roles of left-handed nucleic acids such as Z-DNA – from immunity to controlling our genetics. Rachel Brazil reports
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ResearchUnravelling enzyme pathway of Taxol precursor brings synthetic production of cancer medicine closer
Expression of nine genes in tobacco plants led to formation of complex precursor of drug
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ResearchD-trypsin synthesis enables sequencing of mirror-image proteins
Reversing the chirality of a protein-digesting enzyme could aid the development of mirror-image therapeutics
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BusinessNew Covid-19 antiviral cuts symptoms by 1.5 days
Simnotrelvir already has emergency approval in China
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NewsExplainer: A new antibiotic class has been discovered – how excited should we get?
With 10 million people a year forecast to die a year as a result of antimicrobial resistance by 2050 many new antibiotics are urgently needed
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ResearchMachine learning identifies promising antibacterial ruthenium-based drug candidates
Algorithm demonstrated a success rate six times higher than a random screening against resistant bacteria
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OpinionExploring new fragments of chemical space
How medicinal and process chemists are working together to build better drugs
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BusinessPharmaceuticals roundup 2023
Regulatory and pricing reforms have topped industry agendas in 2023, while weight loss drugs surged and Covid-19 therapies waned
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FeatureCubanes help drugs take the strain
Medicinal chemists are increasingly exploring strained ring systems, George Barsted reports, believing they can serve as replacements for conventional building blocks in pharmaceuticals
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ResearchAntibiotic adjuvant designed to subvert bacterial defence mechanisms
Amphiphilic molecule helps obsolete antibiotics accumulate and act within bacteria
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BusinessWeight-loss drug shortages prompt copycats and counterfeits
Novo Nordisk and Eli Lilly have struggled to meet huge demand for new hormone mimic obesity treatments
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ResearchUnderwater device reveals marine chemical diversity
I-Smel device probes metabolites produced by Mediterranean sponges
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FeatureBattling long Covid with drugs
The challenge of finding drugs for a poorly understood disease with many symptoms is clear. Clare Sansom looks at the work going on to help the people suffering in its shadow
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OpinionLetters: October 2023
Readers discuss antibiotic challenges, muse about micrographs and remember Philip Eaton
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NewsmRNA vaccine pioneers win medicine Nobel prize
Katalin Karikó and Drew Weissman honoured for breakthroughs that enable the rapid development of new vaccines, including several of those used against Covid-19
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FeatureThe drug developers fighting the antibiotic resistance problem
Andy Extance talks to the researchers innovating across different drug classes in the hunt to develop new treatments
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BusinessHow can we maintain the effectiveness of existing antimicrobials?
Reducing environmental pollution and tackling quality issues to stave off resistance