Drug discovery and development – Page 3
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BusinessUS approves twice yearly injection to prevent HIV
Yeztugo (lenacapavir) provided near-total protection against infection in clinical trials
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FeatureHibernation awakens interest for drug discovery
With many different species entering torpor for a variety of reasons, scientists are looking to their sleepy secrets for ways to treat human diseases. Anthony King reports
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ResearchAbundant alkanes become gaseous alkylating agent with flow chemistry
Photocatalytic process can carry out late-stage optimisation of drug candidates
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BusinessSanofi to buy Blueprint Medicines for over $9 billion
Blueprint has one approved drug and enhances Sanofi’s immunology portfolio
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OpinionIgnoring women’s health shouldn’t be an option
Developing therapies for conditions that predominantly affect women is a neglected, but enormous, opportunity
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WebinarModelling amorphous solid dispersion (ASD) release mechanisms
Learn how thermodynamic modelling and molecular simulation can help our understanding of amorphous solid dispersion
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OpinionWomen are not just another confounding factor in drug development
Ignoring physiological differences between the sexes is indefensible
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FeatureManaging the menopause
The end of ovulation will affect almost all women, but current treatments could be improved. Rachel Brazil reports on the efforts to find a better solution
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OpinionIn search of truth and rules
To codify and predict ever more complex phenomena is one of science’s great drivers
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BusinessMerck KGaA to buy cancer specialist SpringWorks
$3.9 billion deal boosts Merck’s pipeline as it faces patent expiries
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ResearchLSD analogue synthesised by swapping just two atoms less likely to cause hallucinations
New molecule shows promise for treating neuropsychiatric conditions such as schizophrenia
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WhitepaperOptimise drug discovery: predicting transporter-mediated drug interactions
Learn how in vitro models, biomarkers and modelling can improve prediction of drug interactions and toxicity – reducing false positives and unnecessary clinical studies
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BusinessFree energy methods and digital transformation of drug discovery
Synergistic application of AI-based generative chemistry and free energy methods streamlines molecule discovery and optimisation
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NewsFears grow over the future of mRNA vaccine research in the US
Researchers working on mRNA vaccines fear federal funding might be halted, with many looking to move projects abroad
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BusinessAcceptable levels of (epi)genetic engineering
Amplifying or silencing genes may be preferable to permanently changing genetic code
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BusinessEpigenetic editors enter clinical trials
New wave of precision medicines amplify or silence genes, without altering genetic code
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BusinessUS regulatory chief’s resignation raises alarms in biotech industry
FDA vaccines and biologicals centre director, Peter Marks, clashed with health secretary Robert F Kennedy Jr
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OpinionWelcome to the MegaPharm target selection and project resourcing meeting
Overheard recently in a seminar room near you…
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OpinionWeight loss drug supply races
With official shortages ended, but the first generics gearing up for launch, companies are looking for the next generation of drugs
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ResearchSkeletal editing targets double bonds
Two new techniques selectively install nitrogen atoms into complex molecules