Drug discovery and development – Page 8
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BusinessUK antibiotics supply chain stretched by surge in Strep A infections
Government enacts protocols to enable substitute treatments and recommends preventive prescriptions in severe cases
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NewsCrispr moves into the clinic
A mere decade after its discovery Crispr is already in clinical trials for everything from sickle cell disease to HIV and cancer
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BusinessPharmaceuticals roundup 2022
Following the huge success of vaccines and treatments for covid-19, companies are upping their investment in R&D and dealmaking
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ResearchUniversal flu vaccine could head off future pandemics
More effective mRNA-based vaccine offers hope of ending annual flu shots for at risk groups
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ResearchSurprise discovery as clam found to be producing complex antibiotic
Erythromycin was previously believed to be only synthesised by bacteria
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ResearchRadium chelator researchers working to improve targeted cancer therapies
Oak Ridge National Lab team investigate factors underpinnning Ra2+ complex stability and selectivity in attempt to expand the therapeutic utility of radium-223
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OpinionEmbracing oddities
When new chemistry looks like alchemy or witchcraft, it’s worth taking notice
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NewsWorld Health Organization takes aim at market as many still not getting vaccines they need
Government, industry and health organisations must do more
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ResearchDiverse pharmaceutical building blocks prepared with evolved enzymes
Computation guides enzyme evolution to produce high-value drug compounds
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ResearchAmide library created at speed with machine learning and stopped-flow chemistry
Approach used 90% less starting material than continuous flow equivalent
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FeatureTiny delivery systems for cancer drugs
Encapsulating anticancer agents in nanoparticles can make them gentler on the rest of the body. Clare Sansom reports
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OpinionNobel vision
Looking beyond the here-and-now let click chemistry open up a whole new world of possibility
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BusinessAlzheimer’s antibody engenders anticipation
Tantalising press-released data on Biogen and Eisai’s lecanemab prompt questions without firm answers
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BusinessAn evolution in pharma outsourcing
Contract services firms are becoming increasingly sophisticated and embedded in the ecosystem of drug development
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OpinionContribute to defeating malaria
The Medicines for Malaria Venture needs new compounds for screening and more chemists to join its open-souce drug discovery project
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Feature50 years of artemisinin
Jamie Durrani tells the story of how a wonder drug against malaria was discovered from a plant in a secret Chinese military project
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ResearchYeast engineered to ferment sugars into chemotherapy drug precursors
Semisynthesis offers new route to anticancer drug vinblastine
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WebinarHow to profit from recent innovations in small molecule drug discovery
Reduce risk, cost and wasted time in the new era of small molecule drug discovery