Drug discovery and development – Page 8
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OpinionEmbracing oddities
When new chemistry looks like alchemy or witchcraft, it’s worth taking notice
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NewsWorld Health Organization takes aim at market as many still not getting vaccines they need
Government, industry and health organisations must do more
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ResearchDiverse pharmaceutical building blocks prepared with evolved enzymes
Computation guides enzyme evolution to produce high-value drug compounds
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ResearchAmide library created at speed with machine learning and stopped-flow chemistry
Approach used 90% less starting material than continuous flow equivalent
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FeatureTiny delivery systems for cancer drugs
Encapsulating anticancer agents in nanoparticles can make them gentler on the rest of the body. Clare Sansom reports
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OpinionNobel vision
Looking beyond the here-and-now let click chemistry open up a whole new world of possibility
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BusinessAlzheimer’s antibody engenders anticipation
Tantalising press-released data on Biogen and Eisai’s lecanemab prompt questions without firm answers
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BusinessAn evolution in pharma outsourcing
Contract services firms are becoming increasingly sophisticated and embedded in the ecosystem of drug development
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OpinionContribute to defeating malaria
The Medicines for Malaria Venture needs new compounds for screening and more chemists to join its open-souce drug discovery project
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Feature50 years of artemisinin
Jamie Durrani tells the story of how a wonder drug against malaria was discovered from a plant in a secret Chinese military project
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ResearchYeast engineered to ferment sugars into chemotherapy drug precursors
Semisynthesis offers new route to anticancer drug vinblastine
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WebinarHow to profit from recent innovations in small molecule drug discovery
Reduce risk, cost and wasted time in the new era of small molecule drug discovery
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WebinarFinding new medicines for malaria
Join Chemistry World for this interactive webinar and explore some of the collaborative avenues of research looking for new medicines to prevent and treat one of our oldest foes.
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ResearchArtificially evolved enzyme tackles tricky cross coupling
Directed evolution on the metalloenzyme cytochrome P450 creates a catalyst for making macrocyclic antibiotics
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BusinessProtective treatment for Covid-19 makes minimal impact
Limited uptake of antibody combination for vulnerable patients, while demand for antivirals seems to be slowing
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OpinionWhy AlphaFold won’t revolutionise drug discovery
Protein structure prediction is a hard problem, but even harder ones remain
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ResearchTeixobactin’s two pronged antibiotic attack mechanism revealed
Understanding of formation of deadly supramolecular structures could help build improved antimicrobials
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OpinionMay cause side effects
The dose makes the poison, but understanding unwanted drug interactions is complicated