Drug discovery and development – Page 8
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ResearchLight-activated cancer treatment uses tumour-targeting enzymes to cut side effects
Enzymatic activation of a photosensitive prodrug in cancerous cells shows promise in mice
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ResearchBreaking bacteria’s genetic silence to synthesise antibiotics that evade resistance
Prospecting in bacterial genomes offers hope in search for new antimicrobial drugs
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BusinessWhat is the future of Covid-19 pharmaceuticals?
Firms anticipate long-term markets for prevention and treatment
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FeatureThe incredible antibodies of sharks, llamas and camels
Sharks and llamas share a strange quirk of their immune systems. Hayley Bennett finds out how their ‘nanobodies’ could help us tackle Covid and a host of other diseases
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ResearchAI tool finds green ways to turn chemical waste into drugs
Circular approach for industry by-products considers environmental, economic and geographic aspects to rank predicted routes for real-world applications
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WebinarSpeed up process development by making more from your offline and online data
Learn how the biotechnology R&D team at Clariant uses statistical modelling techniques to speed up the process development of their bio-ethanol product
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BusinessUK takes subscription approach for new antibiotics
Decoupling payment from prescriptions helps preserve last-line antibiotics and encourage R&D
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NewsUK’s non-profit vaccine manufacturing centre sold off before opening
Pharmaceutical firm Catalent buys government-backed facility near Oxford
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FeatureA decade of CAR-T cell therapy
Nina Notman looks at the revolutionary treatment already taking on cancer, now aiming for wider use
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NewsDrug discovery AI that developed new nerve agents raises difficult questions
Researchers shocked by how easily algorithm discovered novel poisons even deadlier than VX
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OpinionA spanner in the works
Most drugs work by breaking or stopping something, rather than by making something faster or better
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BusinessModerna sued over Covid-19 vaccine-related patents
Arbutus and Genevant say lipid nanoparticles that protect mRNA infringe six key patents
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BusinessTrials start of mRNA vaccine for HIV
First steps towards protection from the many and variable viral strains
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ResearchLeft-handed nanoparticles are far better vaccine adjuvants than their mirror images
Chiral gold nanoparticles shown for the first time to elicit differing immune responses in cells and live mice
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NewsExplainer: How do the Covid vaccines measure up against each other and omicron?
Looking at how the evidence stacks up for vaccines against variants and how their performance holds up over time
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OpinionLetters: February 2022
Readers investigate June Lindsey’s legacy, question policy and celebrate vaccination
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OpinionThe shadow of drug resistance
Why do some medicines stop working, and can we avoid it for Covid-19 antivirals?
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OpinionThe law of conservation of data
AI and machine learning are useful and powerful, but they need high quality data inputs that aren’t available yet for drug discovery
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OpinionWhen regulatory cooperation goes too far, we all lose
Were FDA staff unduly influenced by Biogen in approving Alzheimer’s antibody?
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BusinessPharmaceuticals roundup 2021
It’s been another dramatic, pandemic-dominated year for the pharmaceutical industry