Drug discovery and development – Page 8
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ResearchSoapbark tree’s biosynthetic pathway for vaccine adjuvant saponins
Researchers use genome mining and bioengineering techniques to map out route
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NewsAir jet gun delivers needle-free vaccines in MOFs without any need for refrigeration
Release rate of injector system can be fine-tuned by changing the carrier gas
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BusinessPfizer to buy cancer biotech Seagen for $43 billion
Antibody-drug conjugate specialist will fill Pfizer’s cancer pipeline
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ResearchStudy challenges assumptions over how l-oligonucleotides behave in living systems
L-oligonucleotides are potentially cytotoxic but some could have unexpected therapeutic benefits
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ResearchPeptide tags that encode chemical libraries could revolutionise drug discovery
Simple strings of amino acids store over 4 gigabits of data, offering a highly stable solution for screening small molecule libraries
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ResearchDataset with millions of entries set to help AI find new drugs
Neural networks perform better when trained on larger datasets
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ResearchAlphaFold works with other AI tools to go from target to hit molecule in 30 days
End-to-end AI drug discovery process predicts potential inhibitors for a protein implicated in liver cancer
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BusinessEncoding creativity in drug discovery
Machine learning can complement and reinforce human intuition and experience
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OpinionA decade on Crispr is already poised to deliver on its promise
Gene editing could transform healthcare but no disease should be forgotten
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![Chemical structure of Pillar[6]MaxQ](https://d2cbg94ubxgsnp.cloudfront.net/Pictures/100x67/6/2/1/523621_chempr1747_proof1_891632.jpg)
ResearchMolecular trap that snares many different drugs could save lives during overdoses
Macrocyclic compound can mop up drugs of abuse in animal tests – including those for which no reversal agent exists
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OpinionSetting drug development speed records
The pandemic treatment sprint was spectacular, but hard to match under less unusual circumstances
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ResearchBenchtop machine automates synthesis of drug screening hits
System could boost the efficiencies of drug discovery campaigns
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BusinessUK antibiotics supply chain stretched by surge in Strep A infections
Government enacts protocols to enable substitute treatments and recommends preventive prescriptions in severe cases
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NewsCrispr moves into the clinic
A mere decade after its discovery Crispr is already in clinical trials for everything from sickle cell disease to HIV and cancer
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BusinessPharmaceuticals roundup 2022
Following the huge success of vaccines and treatments for covid-19, companies are upping their investment in R&D and dealmaking
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ResearchUniversal flu vaccine could head off future pandemics
More effective mRNA-based vaccine offers hope of ending annual flu shots for at risk groups
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ResearchSurprise discovery as clam found to be producing complex antibiotic
Erythromycin was previously believed to be only synthesised by bacteria
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ResearchRadium chelator researchers working to improve targeted cancer therapies
Oak Ridge National Lab team investigate factors underpinnning Ra2+ complex stability and selectivity in attempt to expand the therapeutic utility of radium-223
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OpinionEmbracing oddities
When new chemistry looks like alchemy or witchcraft, it’s worth taking notice
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NewsWorld Health Organization takes aim at market as many still not getting vaccines they need
Government, industry and health organisations must do more