All Drug discovery and development articles – Page 5
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BusinessCoronavirus variants stymie success of monoclonal antibodies
Lab-made antibodies can treat and protect people from Covid-19 but are more likely to succeed when administered as a cocktail
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Feature
Drugging RNA
Some medicinal chemists have changed their focus from proteins to target RNA, finds Rachel Brazil
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Webinar
Physics-based computational modeling applied to the design and optimisation of biologics
Explore how FEP technology (including FEP+) can be applied in protein engineering work
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Sponsored
AstraZeneca puts academia at the heart of pharma
At the heart of chemical biology are the molecules that make medicines effective and safe for consumers. AstraZeneca harnesses the scientists at the heart of academia to create a healthier world
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News
Oxford University to open antimicrobial research centre after £100m donation from Ineos
Petrochemical giant highlights dangers of antibiotic resistance
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Opinion
Ruling out the rule of five
Simple calculations for clinical trial success failed to find a winning formula
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News
Decoding the virus – what we know about Sars-CoV-2 a year on
Scientists have never learnt so much about a pathogen in such a short time
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Webinar
High-throughput reaction screening for accelerated materials research
Learn how structure-property relationships can be used to re-design reactions or catalysts to achieve a desired activity
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Business
Vaccine approvals offer hope as global Covid cases surge
A handful of vaccines are now approved and the first doses are being given to patients, with trials for many more candidates nearing completion
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Business
Pharmaceuticals roundup 2020
Alongside the race for Covid-19 treatments and vaccines, the industry has maintained momentum
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Webinar
Faster drug discovery and optimisation with physics-based computational methods
Learn how physics-based computational methods, such as Free Energy Pertubation (FEP) calculations, can speed up the drug discovery and lead optimisation
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Research
Chemists tame shamanic addiction treatment
Animal experiments show modified structures remove ibogaine’s hallucinogenic and heart-harming effects
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Feature
2020: the year the world changed
Andy Extance discovers how scientists around the world have responded to the pandemic, working on solutions from drugs and vaccines to hand sanitiser and PPE
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Business
Pfizer–BioNTech vaccine gains emergency approvals in US, Canada and beyond
UK begins vaccinating vulnerable populations after early authorisation
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Research
Animal tests reveal synthetic decoy protein protects against coronavirus
Protein designed from scratch binds Sars-CoV-2 with high affinity and specificity
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Business
UK grants Pfizer–BioNTech Covid-19 vaccine emergency approval
Regulators around the world working towards accelerated decisions on vaccine data
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Business
Oxford–AstraZeneca vaccine joins others with promising interim data
Cheap and fridge-stable candidate at least 60% and up to 90% effective at preventing disease
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Business
Regulatory panel unconvinced by Alzheimer’s antibody evidence
US FDA advisors vote against approving Biogen’s aducanumab on the basis of incomplete data analysis
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Webinar
Emerging strategies in covalent inhibition
Join us for a review of emerging strategies for the development of covalent inhibitors in drug discovery
