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ResearchFlow synthesis produces chiral intermediate for antidepressant drug
The first solvent-free organocatalytic flow process yields the key chiral intermediate for paroxetine on a multigram-scale
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News
Swipe right to help in the fight against Huntington’s disease
Citizen science project improves understanding of protein misfolding disorders like Huntington’s and Alzheimer’s diseases
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Research
Biomimetic synthesis cultivates yellow poppy pigment
Cascade process that fuses indole with orientalin verifies biosynthesis of nudicaulins
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Research
Chronic exposure to battery nanomaterial leads to resistant bacteria
Shewanella onedensis MR-1 adapts to media spiked with complex metal oxide nanoparticles
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Opinion
Will computers ever discover drugs from scratch?
With enough understanding and computing power, it should be possible, but will it happen?
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News
Twitter reveals growing global public anxiety about Crispr gene-editing
Sentiment in tweets shows controversial events such as creation of gene-edited babies is worrying people
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Research
Synthetic hormone stops water loss in crops
Virtual screening and scaffold merging behind compound that closes plant stomata
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Research
Ammonium bicarbonate trick enables sophisticated lipid analysis
Tandem mass spectrometry method can distinguish lipid isomers
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News
Study claiming gene-edited babies were more likely to die young was wrong
Database bias introduced major error in a now retracted study on Crispr babies’ mortality
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Podcast
Hypoxia-inducible factors – HIFs
The oxygen sensors that help life react to changing conditions, key to the 2019 Nobel prize in physiology or medicine
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Research
Secret of super-tough scales of giant Amazonian fish uncovered
Spiral-staircase structure prevents the scales being penetrated by piranhas
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Business
The rise of venture philanthropy
More and more charities are investing in companies, and looking for returns on that investment, as an alternative to traditional grants
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Business
Nitrosamine contamination withdrawals spread to new drugs
After ranitidine recalls, EU regulators instruct companies to review all their products for potential impurities
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Research
Unified synthesis shows how genetic alphabet could have been put together on early Earth
Cycles of wet and then dry conditions provide the right conditions to make all the nucleobases from basic chemicals
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Research
Cryogenic properties could promote silkworm fibres into space exploration
Combination of intrinsic and extrinsic mechanisms allows silks to retain both toughness and ductility at extremely low temperatures
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Research
Alzheimer’s therapy has click chemistry use, then remove, brain copper build-ups
In situ drug synthesis catalysed by endogenous copper
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Research
Metallohelices emulate antimicrobial peptides
Scientists move away from traditional drug candidates to evade resistance
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Business
Sixth in a line of Alzheimer’s drugs fails in trials
Treatments designed to stop amyloid peptide formation all seem to cause cognitive impairment rather than prevent it
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Article
Richard Henderson: ‘I rejected the phone call, and then noticed it was from Sweden…’
The 2017 laureate tells his story
