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ResearchAlphaFold works with other AI tools to go from target to hit molecule in 30 days
End-to-end AI drug discovery process predicts potential inhibitors for a protein implicated in liver cancer
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Business
Encoding creativity in drug discovery
Machine learning can complement and reinforce human intuition and experience
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Opinion
A decade on Crispr is already poised to deliver on its promise
Gene editing could transform healthcare but no disease should be forgotten
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Research
Oyster mushroom unleashes chemical warfare on its nematode prey
Fungus discovered to be using 3-octanone to paralyse and kill worms
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Feature
Omega-3s and brain health
Modern diets can leave us short on essential fatty acids. Barbara Pinho looks into how this is affecting our health and our brains in particular
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Opinion
Protein filaments allow ‘diary’ of cell events to be read
Expression recording islands show when and where cells responded
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Business
Second Alzheimer’s antibody approved in the US
Biogen–Eisai’s lecanemab can slow disease progression a little, but at significant cost and risk of side effects
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Research
Molecular trap that snares many different drugs could save lives during overdoses
Macrocyclic compound can mop up drugs of abuse in animal tests – including those for which no reversal agent exists
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Opinion
Setting drug development speed records
The pandemic treatment sprint was spectacular, but hard to match under less unusual circumstances
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Business
Anti-drift additives may volatilise alongside herbicides, causing pollution
Research suggests amine salts could be entering atmosphere, but manufacturers say lab model is unrealistic
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Research
Proteins behind diatoms’ intricate nanoscale-patterned shells revealed
Finding could help pattern materials for photonics, catalysis and sensors
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Research
Benchtop machine automates synthesis of drug screening hits
System could boost the efficiencies of drug discovery campaigns
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Opinion
Exploring AlphaFold’s knowledge of energy landscapes
The algorithm needs a little help to find the global energy minimum
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Business
UK antibiotics supply chain stretched by surge in Strep A infections
Government enacts protocols to enable substitute treatments and recommends preventive prescriptions in severe cases
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News
Crispr moves into the clinic
A mere decade after its discovery Crispr is already in clinical trials for everything from sickle cell disease to HIV and cancer
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Feature
Are everyday chemicals contributing to global obesity?
Research in animal models suggests the simple ‘energy in, energy out’ model doesn’t tell the whole story. Anthony King talks to researchers worried about obesogens
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News
Europe’s largest, hi-tech life sciences building is planned for UK
With lab space in the UK in short supply, a British property firm and Dutch real estate developer are building a massive vertical campus in London
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Business
Judge dismisses ranitidine lawsuits over lack of evidence
Drug degrades to produce nitrosamines, but the judge ruled the link between this and plaintiffs’ cancers could not be proven
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Business
Theranos leaders to be imprisoned for blood testing fraud
Sunny Balwani and Elizabeth Holmes will both serve more than 10 years
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Research
Nanoplastics disrupt ubiquitination in human cells
High-resolution study mapping nanoparticle–protein interactions builds understanding surrounding health implications of plastic contamination
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