Medicinal chemistry – Page 13
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OpinionFurin fundamentals
There’s no direct evidence for the lab leak hypothesis – and the biochemistry of the virus might not tell us much about it
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ResearchBiochemical mystery unfolds as elemental metals found in Alzheimer’s patients’ brains
In a discovery that raises more question than it answers, researchers have found zero-oxidation-state iron and copper deposits inside amyloid plaques
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ResearchProtein impurities found in AstraZeneca’s Covid-19 vaccine stir debate
Compounds might cause side effects but are unlikely to be behind extremely rare blood-clotting events
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NewsHints that century-old TB vaccine offers an immune boost against Covid-19
Small study is part of global effort examining whether the BCG jab could help in the next pandemic
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ResearchSynthetic overhaul for hepatitis C drug could ease manufacturing demands
Chemists hope their five-step synthesis will increase global accessibility of uprifosbuvir and other lifesaving antivirals
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BusinessMorphosys agrees to buy cancer epigenetics specialist Constellation
$1.7bn deal will be funded by selling rights to royalties on existing drugs
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ArticleSustainable safety testing
Unilever has been researching and applying alternatives to animal testing, and working with industry, academia, government scientists and NGOs to usher in a new era of sustainable safety testing that isn’t reliant on animal models.
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BusinessStriving to bolster the antibiotic pipeline before it becomes the next crisis
It’s been almost 10 years since the world was warned of a post-antibiotic apocalypse. Katrina Megget takes a look at the initiatives trying to support antimicrobial R&D
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ResearchPollen-mimicking antidote saves bees after pesticide exposure
Calcium carbonate microparticles deliver detoxifying enzyme to bees’ guts
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NewsPromotion of Covid-19 pseudoscience by Indian government criticised as pandemic rages
Questionable therapies under study or promoted include prayer, breathing exercises and herbal medicines
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OpinionThe side effects of being unique
Even the largest clinical trials won’t capture all possible bad reactions to a drug – we need pharmacovigilance
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ResearchClick chemistry uses endogenous acrolein to activate cancer prodrug
Strategy could reduce chemotherapy side effects by selecting for cancerous cells
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NewsUS onboard with effort to waive global Covid-19 vaccine patents
Biden administration says pandemic calls for ‘extraordinary measures’ to relinquish IP protections, but pharma and biotech sectors push back
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OpinionEmbracing the exposome
Analytical research strategies are evolving to keep up with the chemical complexities of our world
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OpinionLetters: May 2021
Readers ponder hydrogel vaccine distribution and life with hearing difficulties
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ResearchTri-agonist molecule designed to stimulate immune system crosstalk
Conjugation chemistry connects three different agonists around a triazine core
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NewsUS urged to waive Covid-19 vaccine patents
175 former world leaders and Nobel laureates call on Joe Biden to suspend intellectual property rules
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WebinarMolecular modeling for the medicinal chemistry toolkit
Join us to discover how to streamline your workflows using integrated software solutions for docking, ligand design, and optimisation
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ResearchCoffee pods and 3D printing combine to create cheap and quick Covid-19 tests
Repurposed aluminium capsules enable a point-of-care test ideal for remote and low-income settings
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ResearchIngestible COF that delivers insulin could help diabetics duck injections
When blood glucose levels are high, glucose displaces insulin loaded in the framework