Medicinal chemistry – Page 12
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Business
Protective treatment for Covid-19 makes minimal impact
Limited uptake of antibody combination for vulnerable patients, while demand for antivirals seems to be slowing
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Opinion
Why AlphaFold won’t revolutionise drug discovery
Protein structure prediction is a hard problem, but even harder ones remain
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Research
Teixobactin’s two pronged antibiotic attack mechanism revealed
Understanding of formation of deadly supramolecular structures could help build improved antimicrobials
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News
Software from Cambridge crystallographic experts could save pharma industry millions
Informatic tools will help drug formulators understand particle behaviour in their final product
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Opinion
May cause side effects
The dose makes the poison, but understanding unwanted drug interactions is complicated
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Research
Antigen-carrying adjuvants activate both adaptive and innate immunity
Aluminosilicate nanoparticles promote ion perturbation, pyroptosis and enhanced immunity in a cancer model
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Business
California advances plans to make its own insulin
Governor commits $100 million to develop low-cost insulin and build manufacturing facility to strengthen drug’s supply chain
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Business
Second Theranos executive convicted of fraud
Blood testing startup president Ramesh ‘Sunny’ Balwani defrauded both investors and patients
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Opinion
Alzheimer’s, amyloid and abandoned antibodies
Biogen’s aducanumab is stumbling into obscurity. Where does that leave the amyloid hypothesis?
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Research
Molecular machine drills holes in antibiotic-resistant bacteria killing them
Bacteria aren’t able to develop resistance against nanomotor’s deadly action
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News
New questions raised over Sputnik Covid vaccine results point to fraudulent practices
Analysis comparing Sputnik results with five other Covid vaccines finds phase 3 trial outcome is highly improbable
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Research
Encapsulated bacteria show promise as injectable living drugs factories to treat diseases
Engineered E. coli produce insulin and vaccines in vivo
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Business
Soapbark branches out to fill essential role in vaccine recipes
The soapbark tree has long been used in traditional medicines, but is now coveted for some of our newest vaccines
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Feature
Using genetics to personalise prescriptions
We’ve known for a long time that different people respond to certain drugs to very different extents, but now cheap DNA testing could make these disparities a thing of the past, as Ian Le Guillou reports
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Research
Light-activated cancer treatment uses tumour-targeting enzymes to cut side effects
Enzymatic activation of a photosensitive prodrug in cancerous cells shows promise in mice
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Research
Breaking bacteria’s genetic silence to synthesise antibiotics that evade resistance
Prospecting in bacterial genomes offers hope in search for new antimicrobial drugs
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Research
Gut microbiome analysis spots sleep-deprived mice
Fluorescence-based sensing array that identifies bacteria in stool samples could be developed into a tool for diagnosing various conditions
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Business
What is the future of Covid-19 pharmaceuticals?
Firms anticipate long-term markets for prevention and treatment
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Research
Cancer progression and harmful bacteria tracked with next-generation sequencing
Proof-of-principle study keeps an eye on leukaemia mutations and bacterial strains in patients