Medicinal chemistry – Page 11
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OpinionGLP-1 drugs could be more than a win–win for weight loss
Semaglutide and tirzepatide are changing lives, and could change our attitudes
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FeatureThe GLP-1 weight loss revolution
Glucagon-like peptide-1 agonist drugs, such as semaglutide, could save countless lives at risk due to diabetes and obesity. Rachel Brazil looks at the difficulties in making the peptides themselves, and what’s coming next
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OpinionProteins’ shape and function are two sides of the same coin
A new perspective on the relationship between chemistry and biology
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BusinessMDMA rejection poses questions for psychedelic drug trials
Decision prompts reflection over how psychotherapy is involved, regulating combination treatments and safeguarding patients
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ResearchPotential new class of antibiotics takes on flesh-eating infections
Peptide-mimicking compounds target bacterial cell walls
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ResearchInnovative antibacterial strategy shows promise for treating infections
New antibiotic mechanism sees molecule infiltrate bacterial cells and destroy them from the inside
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ResearchAnalytical chemistry tools point to the future of personalised medical diagnostics
Molecular fingerprinting techniques outperform standard blood tests for detecting the onset of many diseases
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OpinionMedicinal chemistry’s biological blind spots
Despite advances in modern medicine, there are some big gaps in our knowledge
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ResearchTherapeutic proteins can hitch a ride on parasite to bypass blood-brain barrier
Toxoplasma could be delivery agent for protein drugs – provided parasite can be made safe
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BusinessWeight-loss drugmakers bet billions on boosting supplies
Eli Lilly and Novo Nordisk invest to expand in-house manufacturing of GLP-1 drugs
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ResearchDrugs and vaccines could be freed from cold chains by hydrogel
Stiff gel prevents proteins from aggregating, preserving their therapeutic power
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ResearchNanopore proteins designed from scratch and turned into biosensors
Artificial ion channels used to detect disease indicators and pharmaceuticals
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ResearchCompanion compound for naloxone could boost opioid reversal effects, save lives
Discovery could help in fight against super-strength opioids such as fentanyl
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FeatureWhy don’t we know how antidepressants work yet?
Selective serotonin reuptake inhibitors are at the centre of a collision between social and biochemical outlooks on depression, finds Andy Extance
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FeatureBypassing the blood–brain barrier
Researchers are on a quest to outsmart and overcome the sophisticated security system of the brain. Julia Robinson reports on some of the approaches being studied
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OpinionUnderstanding our brains is complicated, beware of simple ideas
Stepping up from chemistry to complexity
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FeatureThe high price of a suntan
Skin cancer is on the rise in many countries around the world, but so are the methods to treat it. Bárbara Pinho reports
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BusinessModerna’s mRNA vaccine approved for RSV
US approval adds complementary option to protein-based vaccines for respiratory syncytial virus
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ResearchConjugate vaccine curbs xylazine effects in mice
Proof-of-concept for therapy that harnesses immune system to fight fentanyl adulterant
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OpinionWill science ever reach an end?
While the rate of discoveries in any field may slow over time, the frontier creeps ever further