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ResearchSortase A strategy could see ribosomal products reach further across chemical space
Compound libraries set to benefit from process that harnesses promiscuity of post-translation enzymes
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Research
Blocking bacteria’s self-poisoning mechanism weakens their antibiotic resistance
Stopping bacteria from producing hydrogen sulfide in response to drugs could help overcome antimicrobial resistance
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Opinion
Furin fundamentals
There’s no direct evidence for the lab leak hypothesis – and the biochemistry of the virus might not tell us much about it
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Research
Biochemical mystery unfolds as elemental metals found in Alzheimer’s patients’ brains
In a discovery that raises more question than it answers, researchers have found zero-oxidation-state iron and copper deposits inside amyloid plaques
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Research
New class of biomolecule baffles scientists
GlycoRNAs found across several cell types and organisms
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Research
Chloroplasts enhanced with artificial dyes adsorb more solar energy
AIEgen-modified chloroplasts can adsorb ultraviolet radiation and increase the efficiency of photosynthesis
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Opinion
Free radicals for post-translational modification
A technique for forming new carbon–carbon bonds at specific sites in proteins
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Research
Pollen-mimicking antidote saves bees after pesticide exposure
Calcium carbonate microparticles deliver detoxifying enzyme to bees’ guts
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Research
Peptide ligation strategy unlocks diverse range of structural motifs
Approach expected to influence design of protein–protein interaction inhibitors
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Research
Case closed on decades old mystery of American bald eagle deaths
Invasive plant and cyanobacterium join up to form a deadly duo that have been killing US wildlife
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Research
Redox switches up possibilities for signal transduction in artificial cells
Vitamin C triggers membrane translocation in a synthetic system, which generates an amplified fluorescent response
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Research
Walking protein’s tiny steps measured with germanium nanospheres
Highest ever resolution measurements suggests answer to kinesin dispute
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Research
Segregation strategy for methane conversion enables new chemical reactivity
Model built to quantify effect of compartmentalisation on organometallic reaction
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News
Oxford University to open antimicrobial research centre after £100m donation from Ineos
Petrochemical giant highlights dangers of antibiotic resistance
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News
Decoding the virus – what we know about Sars-CoV-2 a year on
Scientists have never learnt so much about a pathogen in such a short time
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Feature
DNA machines get a move on
Devices made from nucleic acids are starting to find their feet, says Nina Notman
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Research
Fluorescent molecule breaks size record for green-emitting dyes
Study identifies 14-atom fluorophore with range of potential biological applications
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Research
The chemical motive for giant pandas’ smelly winter habits
Compounds in fresh manure can desensitise the giant mammals to cold weather
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Research
Google’s AI aces protein prediction competition
Deep-learning network AlphaFold2’s perfomance at predicting how proteins fold has caused great excitement in the scientific community
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Feature
How does a cell know what kind of cell it should be?
Philip Ball investigates how cells use condensed ‘blobs’ to collect the molecules involved in regulating genes
