Chemotherapy and cancer drugs
The latest chemistry news and research on chemotherapy and cancer drugs, including antibodies and immuno-oncology, from the Royal Society of Chemistry's magazine, Chemistry World
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BusinessUS approves pancreatic cancer treatment that targets ‘undruggable’ proteins
Daraxonrasib success offers hope of further approvals for Ras-inhibitor drug candidates targeting various cancers
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PodcastAdvances in CAR-T cancer therapy & carbon materials’ hidden defects
What does recent success with bladder tumours mean for solid cancer treatment? And we discuss why scientists are rethinking how they assign peaks in spectra of carbon-based materials.
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BusinessProtein degrader approval offers hope to relapsed multiple myeloma patients
Highly potent molecular glue drug iberdomide doubles the number of patients reaching fewer than one myeloma cell per 100,000 in bone marrow
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FeatureCracking the ubiquitin code to unlock new drug targets
The approval of the first Protac cancer drug marks a turning point in medicine – but scientists are only beginning to decode the complex molecular language that makes it possible
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ResearchStep forward for CAR-T therapy as it shows promise in solid bladder tumours
Animal tests show targeting bladder cancer specific protein can treat tumours and could cut need for surgery
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ResearchCovalent drugs just got a new ‘spring-loaded’ warhead
Sulfur(IV) reagent allows late-stage installation of bicyclobutanes to drug molecules, expanding a limited tool box
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OpinionGSK agrees $10 billion deal for Nuvalent cancer drugs
Deal includes two late-stage molecules to augment GSK’s renewed cancer therapy pipeline
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PodcastVanadium-based medicines & sustainable labs
Vanadium-based medicines? We discuss the 23rd element’s little-known potential in pharmaceuticals. Plus, how labs across the UK are making achievable changes to increase their sustainability.
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ResearchVanadium’s promise in medicine and the researchers who refuse to give up
It mimics phosphate, kills cancer cells in the lab and almost changed how we treat diabetes. So why has a vanadium compound never made it to the clinic?
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ResearchCrystal structure prediction reaches new heights with axitinib
Computational strategy predicts complex polymorphs and distinguishes salts from co-crystals
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WebinarDeveloping a CITK protein degrader using the QuicTPD™ platform
Learn about the latest technology to accelerate the design of cancer treatments
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ResearchAI tools turned to creating designer proteins for personalised cancer therapies and antibiotics
Powerful new class of AI model could dramatically speed up process of producing new kinds of drug candidates
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BusinessMerck KGaA to buy cancer specialist SpringWorks
$3.9 billion deal boosts Merck’s pipeline as it faces patent expiries
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NewsFears grow over the future of mRNA vaccine research in the US
Researchers working on mRNA vaccines fear federal funding might be halted, with many looking to move projects abroad
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FeatureThe promise of drugs that send proteins to the shredder
Andy Extance charts how research into revolutionary targeted protein degradation therapies is moving from serendipity to strategic discovery
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ResearchAI tool learns to build molecules fragment by fragment
Software tasked with designing a type-II kinase inhibitor suggests 97 candidates in 10 minutes, three of which were both synthesisable and effective at micromolar and nanomolar concentrations
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WebinarEmerging routes to new therapeutics: Highlights from winning Horizon Prize teams
Discover how new therapeutics have the potential to address unmet medical needs
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WebinarThe science and promise of liquid biopsies: improving cancer treatment
Learn how liquid biopsies are being used to identify cancer and improve patient outcomes
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FeatureThe high price of a suntan
Skin cancer is on the rise in many countries around the world, but so are the methods to treat it. Bárbara Pinho reports
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BusinessPan-cancer approval shows huge potential for antibody–drug conjugates
Enhertu gains approval based on gene expression rather than tumour location