All articles by Derek Lowe – Page 2
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OpinionMay cause side effects
The dose makes the poison, but understanding unwanted drug interactions is complicated
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OpinionAlzheimer’s, amyloid and abandoned antibodies
Biogen’s aducanumab is stumbling into obscurity. Where does that leave the amyloid hypothesis?
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OpinionCatalogues of complexity
The tangled web of fine chemicals supply frequently throws up surprises
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OpinionExit strategy
Overcoming a major setback showed Derek Lowe could make it through graduate school
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OpinionA spanner in the works
Most drugs work by breaking or stopping something, rather than by making something faster or better
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OpinionScents and sentimentality
Deprived of familiar lab odours, Derek Lowe indulges in some nasal nostalgia
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OpinionThe shadow of drug resistance
Why do some medicines stop working, and can we avoid it for Covid-19 antivirals?
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OpinionThe law of conservation of data
AI and machine learning are useful and powerful, but they need high quality data inputs that aren’t available yet for drug discovery
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OpinionReverse combustion is preparing for takeoff
Where burning hydrocarbons is unavoidable, creating them from atmospheric carbon is a promising option
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OpinionAll work and no play
Is the long-hours culture of academic organic chemistry laboratories finally changing?
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OpinionWhere are the Covid-19 drugs?
Small molecules appear to be lagging behind development of vaccine and antibody treatments
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OpinionThe price of failure
Drug market structures and high R&D failure rates can tempt companies into bad pricing behaviour
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OpinionPutting combustion into reverse
Unburning carbon dioxide economically and at scale is a tough problem, but potentially world-changing
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OpinionOpening up a cellular black box
Working out how biomolecular condensates work may reveal a lot about the success or failure of different drugs
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OpinionThe side effects of being unique
Even the largest clinical trials won’t capture all possible bad reactions to a drug – we need pharmacovigilance
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OpinionA powerful blow against misconduct
Supporting whistleblowers is vital for detecting and preventing bad behaviour
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OpinionHow the pandemic might change drug research
Derek Lowe muses on some positive lessons learned
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OpinionA rough guide to pharma partnership deals
Coronavirus vaccines are driving unusual collaborations with a range of benefits
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OpinionRuling out the rule of five
Simple calculations for clinical trial success failed to find a winning formula
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OpinionStirring in my sleep
Cut off from the lab after 40 years, Derek Lowe returns to the bench in his dreams