All articles by Derek Lowe – Page 3
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OpinionThe ins and outs of vaccine trials
Derek Lowe lays out how the trials work, and why they get paused and restarted
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OpinionThe Nobel prize that got binned
Ferrocene is a classic example of a discovery that was dismissed as a failed experiment
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OpinionBlood offering
Antibodies in various forms could bridge the Covid-19 treatment gap until a vaccine is available
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OpinionFrom collaboration to collusion
The US government’s crackdown on academics not declaring Chinese funding highlights a moral hazard
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OpinionDragons of immunology
Anti-inflammatories like dexamethasone are triumphs amid the pitfalls of the immune system
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OpinionDoes the drug work, or not?
Coronavirus trials reveal the murky reality of disentangling compounds’ effects on human biology
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OpinionVaccine development against the clock
How long will it take to develop a coronavirus vaccine and why is it so hard?
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OpinionWhy picking projects is like poker
Sometimes you prefer the high-risk, high-reward project to the ‘sure thing’
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OpinionTwo heads are better than one
Bifunctionals show that sometimes simply tethering two useful molecules together unlocks some useful activity
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OpinionReviewing performance reviews
Assessing the value of researchers’ work is hard, but there are some easy ideas to avoid
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OpinionWill computers ever discover drugs from scratch?
With enough understanding and computing power, it should be possible, but will it happen?
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OpinionEmbracing structural disorder
Medicinal chemists need to overcome their fear of fuzzy proteins
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OpinionHas x-ray had its day?
Will the giant of structure determination be toppled by blasts from electron beams?
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OpinionThe silent rise of the robots
Mechanical helpers have been creeping into our labs for decades
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OpinionIs this a golden age of new drug classes?
A host of new treatment modes are hitting the clinic and the market
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OpinionIt's complicated
In a complex world, binary answers are often requested but rarely sufficient
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Opinion
Management by numbers
Reducing intellectual processes to metrics runs the risk of people working to the numbers not the goal