All articles by Derek Lowe – Page 6
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Opinion
How much does fashion influence chemists?
Is that new reaction the next Nobel-worthy breakthrough, or just a flash in the pan?
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Careers
The trials and tribulations of drug discovery
The many pitfalls medicinal chemists face when creating a new drug
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Opinion
Putting chemistry back in biology
The chemical nature of biomolecular interactions can no longer be ignored
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Opinion
Slimmer synthesis
Atom economy is a noble aim, but there are other routes to efficient molecule making
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Opinion
Don’t fear the Crispr
Does simple gene-editing mean the end of traditional medicinal chemistry? Probably not
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Opinion
Now you’re talking my language
Chemistry would be impossible without a hidden fluency that many of us don’t even realise we have, says Derek Lowe
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Opinion
Let's see that again
Has chemistry evaded the reproducibility crises affecting other branches of science? Or is it just a question of scale, asks Derek Lowe
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Opinion
Throwing things over the fence
Saying ‘That’s someone else’s problem’ is asking for trouble, says Derek Lowe
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Opinion
Drugs don’t grow on trees
The trope of companies profiteering from academic discoveries doesn’t bear much scrutiny, says Derek Lowe
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Opinion
Pride comes before a fall
In labs it’s important not to let familiarity breed complacency, says Derek Lowe
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Opinion
Emerging from Babel
Will English ever lose its place as the lingua franca of chemistry, asks Derek Lowe
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Opinion
What the market will bear?
Martin Shkreli’s monopolising model poses some uncomfortable questions for the pharma industry, says Derek Lowe
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Opinion
Spice up your compounds
An occasional foray into uncharted territory is the hot sauce of medicinal chemistry, says Derek Lowe
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Opinion
A risky business
Graduate research is likely the most risky time of a chemist’s career, says Derek Lowe
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Opinion
A precision instrument?
Chemists and biologists have different expectations when it comes to data, says Derek Lowe
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Opinion
Missing the target
There are plenty of things that small molecule drugs can’t touch, says Derek Lowe, and it’s not for want of trying
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Opinion
Magic molecule modifiers
Late stage functionalisation can seem supernaturally powerful, says Derek Lowe – if you’ve got the nerve to try it