All articles by Derek Lowe – Page 6
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OpinionEmerging from Babel
Will English ever lose its place as the lingua franca of chemistry, asks Derek Lowe
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OpinionWhat the market will bear?
Martin Shkreli’s monopolising model poses some uncomfortable questions for the pharma industry, says Derek Lowe
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OpinionSpice up your compounds
An occasional foray into uncharted territory is the hot sauce of medicinal chemistry, says Derek Lowe
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OpinionA risky business
Graduate research is likely the most risky time of a chemist’s career, says Derek Lowe
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OpinionA precision instrument?
Chemists and biologists have different expectations when it comes to data, says Derek Lowe
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OpinionMissing the target
There are plenty of things that small molecule drugs can’t touch, says Derek Lowe, and it’s not for want of trying
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OpinionMagic molecule modifiers
Late stage functionalisation can seem supernaturally powerful, says Derek Lowe – if you’ve got the nerve to try it
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OpinionMissing mathematics?
While you may not need differential calculus every day, mathematics is the basis of scientific thinking, says Derek Lowe
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OpinionAnalogues by catalogue
Buying in screening compounds directly feels like cutting out the synthetic chemist middleman, says Derek Lowe
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OpinionTantalising technology
Computer-assisted drug design always looks like it’s just about to work, says Derek Lowe, but the reality is complicated
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OpinionThe smell of success
Laboratory aromas conjure memories and emotions from elation to a sudden need to vomit, says Derek Lowe
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OpinionIgnorance is no defence
In a chemistry lab, what you don’t know really can hurt you, says Derek Lowe
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OpinionProgress at the pace of the slowest
Chemistry is rarely the rate-limiting process in getting a drug to market, says Derek Lowe
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OpinionChemical space is big. Really big
You think it’s a long way to the back of your screening libraries? That’s peanuts to chemical space, says Derek Lowe
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OpinionGarbage in, garbage out
The rise of low-quality and predatory open access journals and conferences worries Derek Lowe
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OpinionDeath of a reagent
Fashion and progress combine to mean some reactions and reagents persist, while others fall by the wayside, says Derek Lowe
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OpinionThe crystal ball that can tell lies
X-ray structures are not necessarily definitive, says Derek Lowe, especially when it comes to biomolecules
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OpinionToo big to innovate?
How strong is the correlation between company size and research productivity, asks Derek Lowe
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OpinionMessy megamergers
Big company buyouts are more about immediate gains and rarely consider the impact on research, says Derek Lowe